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Biofunctionalization of Ti-15Zr-BASED alloys with molybdenum addition and some surface modifications

Grant number: 15/00851-6
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2015
Effective date (End): October 17, 2017
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Physical Metallurgy
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Luís Augusto Sousa Marques da Rocha
Grantee:Diego Rafael Nespeque Correa
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil


Ti and your alloys are commonly used in the biomedical area, mainly as cardiovascular, orthopedical and dental implants. Its applications occur due your favorable properties, as high mechanical strength and density ratio, relative low Young's modulus, excellent corrosion and wear resistance, further good biocompatibility. The development of new metallic biomaterials has searched for Ti alloys with non-toxic elements, as Zr, Nb, Ta and Mo. Furthermore, there is a special interesting in ²-type Ti alloys (bcc structure) which present lower Young's modulus that could avoid stress shielding effect and implant failure, resulting in a better mechanical compatibility. Zr shows similar chemical properties with the Ti, can improve the mechanical strength and biocompatibility. Mo is a strong ²-stabilizer, can decrease the Young's modulus and improve the corrosion resistance. Currently, the development of new implants has focused in biofunctional and bioactive materials, which presented chemical, physical and mechanical properties proper to the body, in addition to having the ability of healing damaged tissues and cells. This work aims to analyze the electrochemical, physical, mechanical and cytotoxic behavior of the Ti-15Zr-based alloy with the addition of molybdenum, with focus in improve the biofunctionality in terms of composition and microstructure. The influence of different routes of surface modification (like anodization, immobilization of bioactive ions and hydroxyapatite coating) will be evaluated for improve the superficial bioactivity and biofunctionality. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PINTAO, CARLOS A. F.; CORREA, DIEGO R. N.; GRANDINI, CARLOS R.. Torsion modulus as a tool to evaluate the role of thermo-mechanical treatment and composition of dental Ti-Zr alloys. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, v. 8, n. 5, p. 4631-4641, . (07/04094-9, 10/20440-7, 15/00851-6)
CORREA, D. R. N.; KURODA, P. A. B.; LOURENCO, M. L.; BUZALAF, M. A. R.; GRANDINI, C. R.. Adjustment of the microstructure and selected mechanical properties of biomedical Ti-15Zr-Mo alloys through oxygen doping. Journal of Alloys and Compounds, v. 775, p. 158-167, . (10/20440-7, 15/00851-6)
CORREA, D. R. N.; ROCHA, L. A.; DONATO, T. A. G.; SOUSA, K. S. J.; GRANDINI, C. R.; AFONSO, C. R. M.; DOI, H.; TSUTSUMI, Y.; HANAWA, T.. On the mechanical biocompatibility of Ti-15Zr-based alloys for potential use as load-bearing implants. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, v. 9, n. 2, p. 1241-1250, . (10/20440-7, 15/00851-6)
CORREA, D. R. N.; KURODA, P. A. B.; LOURENCO, M. L.; FERNANDES, C. J. C.; BUZALAF, M. A. R.; ZAMBUZZI, W. F.; GRANDINI, C. R.. Development of Ti-15Zr-Mo alloys for applying as implantable biomedical devices. Journal of Alloys and Compounds, v. 749, p. 163-171, . (14/22689-3, 10/20440-7, 12/22742-6, 15/00851-6)
TORRENTO, J. E.; GRANDINI, C. R.; SOUSA, T. S. P.; ROCHA, L. A.; GONCALVES, T. M.; SOTTOVIA, L.; RANGEL, E. C.; CRUZ, N. C.; CORREA, D. R. N.. Bulk and surface design of MAO-treated Ti-15Zr-15Mo-Ag alloys for potential use as biofunctional implants. Materials Letters, v. 269, . (16/25272-1, 15/00851-6)
TIAGO SANTOS PEREIRA SOUSA; NATÁLIA DE ARAUJO DA COSTA; DIEGO RAFAEL NESPEQUE CORREA; LUIS AUGUSTO ROCHA; CARLOS ROBERTO GRANDINI. Morphology, Crystalline Structure and Chemical Composition Of MAO Treated Ti-15Zr-Mo Surfaces Enriched with Bioactive Ions. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 22, n. 6, p. -, . (15/00851-6)
NESPEQUE CORREA, DIEGO RAFAEL; ROCHA, LUIS AUGUSTO; GRANDINI, CARLOS ROBERTO. Mechanical Spectroscopy of Ti-15Zr-based Alloys with Mo Addition. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 20, n. 2, p. 688-693, . (10/20440-7, 15/00851-6)
CORREA, D. R. N.; KURODA, P. A. B.; LOURENCO, M. L.; BUZALAF, M. A. R.; MENDOZA, M. E.; ARCHANJO, B. S.; ACHETE, C. A.; ROCHA, L. A.; GRANDINI, C. R.. Microstructure and selected mechanical properties of aged Ti-15Zr-based alloys for biomedical applications. Materials Science & Engineering C-Materials for Biological Applications, v. 91, p. 762-771, . (14/22689-3, 10/20440-7, 15/00851-6)

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