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Relationship of alpha-adrenergic receptors and bradykinin B2 receptor genes with blodd pressure and left-ventricle mass in individulas without overt heart disease

Grant number: 14/15228-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2015
Effective date (End): October 31, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Rafael Amorim Belo Nunes
Grantee:Larissa Barbosa Lima
Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


The blood pressure and left ventricular mass are physiologic factors associated with cardiovascular health. Pathways such as B2 bradykinin-receptor and alpha-adrenergic receptors play an important role in cardiovascular function and genetic variants of these pathways may impact blood pressure responses and left ventricular mass. We hypothesized that polymorphisms in genes of B2 bradykinin-receptor and alpha-adrenergic receptors may modulate blood pressure and left ventricular mass in individuals without overt heart disease. Methods: the study participants were enrolled from the Project "Saúde cardiovascular em pacientes ambulatoriais" (CAPPesq-HCFMUSP nº 852/03). The participants underwent clinical examination to determine blood pressure, a transthoracic echocardiogram to estimate the left ventricular mass and genotyping of the polymorphisms BDKB2R +9/-9, ADRA1A Arg347Cys e ADRA2A 1780 C>T. We plan to performing statistical analysis with multiple linear regression models.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BELO NUNES, RAFAEL AMORIM; LIMA, LARISSA BARBOSA; TANAKA, NELSON ITHIRO; PEREIRA, ALEXANDRE DA COSTA; KRIEGER, JOSE EDUARDO; MANSUR, ALFREDO JOSE. Genetic associations of bradykinin type 2 receptor, alpha-adrenoceptors and endothelial nitric oxide synthase with blood pressure and left ventricular mass in outpatients without overt heart disease. IJC HEART & VASCULATURE, v. 21, p. 45-49, . (14/15228-0, 09/52992-1)

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