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Evaluation of lead-induced oxidative stress exposure in workers of automotive battery plants

Grant number: 15/04786-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2015
Effective date (End): December 31, 2016
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Gustavo Rafael Mazzaron Barcelos
Grantee:Willian Robert Gomes
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/06033-8 - Combining omics tools for predicting multivariate models in populations exposed to toxic metals, AP.JP


Previous data in the literature suggest that exposure to lead (Pb) results in disorders of cellular redox status leading to oxidative stress and consequently, may cause damage to macromolecules, such as lipids, proteins and DNA. However, most of the work was performed in vitro or in animals models and very little is known about the possible adverse effects related to disturbances of the redox status in humans. The biochemical interactions of Pb with -SH groups are considered one of the most importante toxic mechanisms, since the metal can bind to various endogenous antioxidants such as, for example, the tripeptide glutathione (GSH) and the enzymes glutathione peroxidase enzyme (GPx) and reductase ( GR). Thus, this project aims to evaluate the possible adverse effects induced by exposure to Pb in workers of automotive batteries exposed to metal, in Paraná State, Brazil, by determining the blood concentrations of GSH and the activities of antioxidant enzymes GPx, GR, glutathione synthase (GS) and glutathione S-transferases (GSTs). To this end, metal concentrations will be determined in whole blood by mass spectrometry (ICP-MS) and the determination of GSH and the activities of enzymes GPx, GR, GS and GST will be carried out by spectrophotometry. Thus, it is expected that the results that will be obtained assist for a better understanding of the mechanisms involved in the toxicity induced by exposure to the metal.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DEVOZ, PAULA PICOLI; GOMES, WILLIAN ROBERT; DE ARAUJO, MARILIA LADEIRA; RIBEIRO, DIEGO LUIS; PEDRON, TATIANA; GREGGI ANTUNES, LUSANIA MARIA; BATISTA, BRUNO LEMOS; BARBOSA, JR., FERNANDO; MAZZARON BARCELOS, GUSTAVO RAFAEL. Lead (Pb) exposure induces disturbances in epigenetic status in workers exposed to this metal. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 80, n. 19-21, SI, p. 1098-1105, . (15/04786-4, 14/24981-3, 13/06033-8, 15/07277-3)
GOMES, WILLIAN ROBERT; DEVOZ, PAULA PICOLI; ARAUJO, MARILIA LADEIRA; BATISTA, BRUNO LEMOS; BARBOSA, JR., FERNANDO; MAZZARON BARCELOS, GUSTAVO RAFAEL. Milk and Dairy Products Intake Is Associated with Low Levels of Lead (Pb) in Workers highly Exposed to the Metal. BIOLOGICAL TRACE ELEMENT RESEARCH, v. 178, n. 1, p. 29-35, . (15/04786-4, 14/24981-3, 13/06033-8, 15/07277-3)
GOMES, WILLIAN ROBERT; DEVOZ, PAULA PICOLI; CANO LUIZ, BRUNO LIMONTI; GROTTO, DENISE; BATISTA, BRUNO LEMOS; BARBOSA, JR., FERNANDO; MAZZARON BARCELOS, GUSTAVO RAFAEL. Polymorphisms of genes related to metabolism of lead (Pb) are associated with the metal body burden and with biomarkers of oxidative stress. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v. 836, n. B, SI, p. 42-46, . (13/06033-8, 14/24981-3, 15/07277-3, 15/04786-4, 15/01157-6)

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