Emerging contaminants refer to chemical substances whose interest in studies on the occurrence and effects on the environment is new, and there is a shortage of data related to the occurrence of such contaminants. Among the emerging contaminants stands out bisphenol A (BFA), which has been widely found both in environmental and biological matrices in several countries. Among the various toxic effects already observed after exposure to this compound, we can emphasize the effects on the endocrine system. In Brazil we have scarce data related to exposure to these compounds in population, which has motivated this research project. In this sense, this proposal aims at the use of dispersive liquid-liquid microextraction for the extraction of bisphenol A and its analogues in urine samples and determination of these substances using liquid chromatography coupled with mass detector (LC-MS / MS). For this work two stages will be evaluated: i) development of a dispersive liquid-liquid microextraction (DLLME) for the extraction of bisphenol A and its analogues in urine; II) development of an analytical method using LC-ESI-MS / MS to determine and quantify the bisphenol A and its analogs. After the validation of analytical methods, urine samples will be analyzed and, finally, it is expected that the results of this study can contribute to the knowledge of the levels of exposure to a class of endocrine disruptors that are yet poorly studied in Brazil.
News published in Agência FAPESP Newsletter about the scholarship: