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Physical inactivity and cancer: from evaluation of etiological evidence to public health impact

Grant number: 14/25614-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2015
Effective date (End): February 28, 2019
Field of knowledge:Health Sciences - Collective Health - Epidemiology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:José Eluf Neto
Grantee:Leandro Fórnias Machado de Rezende
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):16/21390-0 - Burden of cancer attributable to lifestyle risk factors in Brazil, BE.EP.DR


Purpose: To investigate the current evidence on the association between physical inactivity and cancer incidence/mortality (Study 1) and the impact of this relationship on public health in Brazil (Studies 2 and 3). Methods: Study 1: we will performe a review (overview) of systematic reviews through a search on 5 databases with descriptors related to exposure ("physical inactivity") and outcome (cancer). From eligible systematic reviews, we will assess the quality through AMSTAR and extract data from the included primary studies. We will also evaluate the existence of publication bias using funnel plot and Egger's test. Study 2: we will estimate population attributable fraction for cancers associated with physical inactivity (type of cancers will be based on study 1 findings) in Brazil. Therefore we will use the following equation: PAF = P(RR-1)/RR where P is the prevalence of physical inactivity among cancer cases in Brazil, and RR are the relative risks extracted from systematic reviews. Study 3: we will evaluate the association between physical inactivity and cancer mortality through an ecological study. Physical inactivity data will be extracted from VIGITEL 2006, including work, domestic, transport, and leisure-time domains in persons aged 30 years or more. Assuming 10-year period between exposure and outcome, cancer mortality rates will be calculated to 2016, extracting information from the Brazilian Mortality Information System. (AU)

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Scientific publications (20)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JOÃO ALEXANDRE MENDES TEIXEIRA; WALESKA REGINA MACHADO ARAUJO; ANA GORETTI KALUME MARANHÃO; JUAN JOSÉ CORTEZ-ESCALANTE; LEANDRO FÓRNIAS MACHADO DE REZENDE; ALICIA MATIJASEVICH. Mortalidade no primeiro dia de vida: tendências, causas de óbito e evitabilidade em oito Unidades da Federação brasileira, entre 2010 e 2015. Epidemiol. Serv. Saúde, v. 28, n. 1, . (14/25614-4)
MACHADO DE REZENDE, LEANDRO FORNIAS; DE SA, THIAGO HERICK; MARKOZANNES, GEORGIOS; REY-LOPEZ, JUAN PABLO; LEE, I-MIN; TSILIDIS, KONSTANTINOS K.; IOANNIDIS, JOHN P. A.; ELUF-NETO, JOSE. Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases. BRITISH JOURNAL OF SPORTS MEDICINE, v. 52, n. 13, p. 826-833, . (14/25614-4)
REY-LOPEZ, JUAN PABLO; DE REZENDE, LEANDRO F. M.. The Obesity Phenotypes in Adolescents: Some Lessons From the HELENA Study. JOURNAL OF ADOLESCENT HEALTH, v. 61, n. 2, p. 266, . (14/25614-4)
LEANDRO FÓRNIAS MACHADO DE REZENDE; JOSÉ ELUF-NETO. Fração atribuível populacional: planejamento de ações de prevenção de doenças no Brasil. Revista de Saúde Pública, v. 50, . (14/25614-4)
LEE, DONG HOON; MACHADO DE REZENDE, LEANDRO FORNIAS; HU, FRANK B.; JEON, JUSTIN Y.; GIOVANNUCCI, EDWARD L.. Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta-analysis. Diabetes/Metabolism Research and Reviews, v. 35, n. 2, . (16/21390-0, 14/25614-4)
MACHADO DE REZENDE, LEANDRO FORNIAS; GARCIA, LEANDRO MARTIN TOTARO; MIELKE, GREGORE IVEN; LEE, DONG HOON; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. Physical activity and preventable premature deaths from non-communicable diseases in Brazil. JOURNAL OF PUBLIC HEALTH, v. 41, n. 3, p. E253-E260, . (16/21390-0, 14/25614-4)
DE SA, THIAGO HERICK; MACHADO DE REZENDE, LEANDRO FORNIAS; BORGES, MARIA CAROLINA; NAKAMURA, PRISCILA MISSAKI; ANAPOLSKY, SEBASTIAN; PARRA, DIANA; ADAMI, FERNANDO; MONTEIRO, CARLOS AUGUSTO. Prevalence of active transportation among adults in Latin America and the Caribbean: a systematic review of population-based studies. Revista Panamericana de Salud Pública = Pan American Journal of Public Health, v. 41, . (12/08565-4, 14/25614-4, 13/25624-7)
MACHADO DE REZENDE, LEANDRO FORNIAS; LEE, DONG HOON; KEUM, NANA; NIMPTSCH, KATHARINA; SONG, MINGYANG; LEE, I-MIN; ELUF-NETO, JOSE; OGINO, SHUJI; FUCHS, CHARLES; MEYERHARDT, JEFFREY; et al. Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II. BRITISH JOURNAL OF CANCER, v. 121, n. 1, p. 86-94, . (16/21390-0, 14/25614-4)
MACHADO DE REZENDE, LEANDRO FORNIAS; TOTARO GARCIA, LEANDRO MARTIN; MIELKE, GREGORE IVEN; LEE, DONG HOON; WU, KANA; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. Preventable fractions of colon and breast cancers by increasing physical activity in Brazil: perspectives from plausible counterfactual scenarios. CANCER EPIDEMIOLOGY, v. 56, p. 38-45, . (16/21390-0, 14/25614-4)
DURAN, ANA CLARA; ANAYA-BOIG, ESTHER; SHAKE, JOSHUA DANIEL; TOTARO GARCIA, LEANDRO MARTIN; MACHADO DE REZENDE, LEANDRO FORNIAS; DE SA, THIAGO HERICK. Bicycle-sharing system socio-spatial inequalities in Brazil. JOURNAL OF TRANSPORT & HEALTH, v. 8, p. 262-270, . (12/08565-4, 14/25614-4, 13/25624-7, 16/17043-2, 15/19131-3)
LEE, DONG HOON; MACHADO DE REZENDE, LEANDRO FORNIAS; ELUF-NETO, JOSE; WU, KANA; TABUNG, FRED K.; GIOVANNUCCI, EDWARD L.. Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response. International Journal of Cancer, v. 145, n. 2, p. 360-369, . (16/21390-0, 14/25614-4)
MACHADO DE REZENDE, LEANDRO FORNIAS; REY-LOPEZ, JUAN PABLO; DE SA, THIAGO HERICK; CHARTRES, NICHOLAS; FABBRI, ALICE; POWELL, LAUREN; STAMATAKIS, EMMANUEL; BERO, LISA. Reporting bias in the literature on the associations of health-related behaviors and statins with cardiovascular disease and all-cause mortality. PLOS BIOLOGY, v. 16, n. 6, . (14/25614-4, 16/21390-0)
MELO, B.; REZENDE, L.; MACHADO, P.; GOUVEIA, N.; LEVY, R.. Associations of ultra-processed food and drink products with asthma and wheezing among Brazilian adolescents. PEDIATRIC ALLERGY AND IMMUNOLOGY, v. 29, n. 5, p. 504-511, . (14/25614-4)
MACHADO DE REZENDE, LEANDRO FORNIAS; AZEREDO, CATARINA MACHADO; CANELLA, DANIELA SILVA; LUIZ, OLINDA DO CARMO; LEVY, RENATA BERTAZZI; ELUF-NETO, JOSE. Coronary heart disease mortality, cardiovascular disease mortality and all-cause mortality attributable to dietary intake over 20 years in Brazil. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 217, p. 64-68, . (14/25614-4)
RAUBER, FERNANDA; DA COSTA LOUZADA, MARIA LAURA; STEELE, EURIDICE MARTINEZ; DE REZENDE, LEANDRO F. M.; MILLETT, CHRISTOPHER; MONTEIRO, CARLOS A.; LEVY, RENATA B.. Ultra-processed foods and excessive free sugar intake in the UK: a nationally representative cross-sectional study. BMJ OPEN, v. 9, n. 10, . (14/25614-4, 16/14302-7, 15/14900-9)
AZEREDO, CATARINA MACHADO; DE REZENDE, LEANDRO F. M.; MALLINSON, POPPY ALICE CARSON; RICARDO, CAMILA ZANCHETA; KINRA, SANJAY; LEVY, RENATA B.; BARROS, ALUISIO J. D.. Progress and setbacks in socioeconomic inequalities in adolescent health-related behaviours in Brazil: results from three cross-sectional surveys 2009-2015. BMJ OPEN, v. 9, n. 3, . (16/21390-0, 14/25614-4)
MACHADO DE REZENDE, LEANDRO FORNIAS; ARNOLD, MELINA; RABACOW, FABIANA MALUF; LEVY, RENATA BERTAZZI; CLARO, RAFAEL MOREIRA; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. The increasing burden of cancer attributable to high body mass index in Brazil. CANCER EPIDEMIOLOGY, v. 54, p. 63-70, . (16/21390-0, 14/25614-4)
JUAN PABLO REY-LÓPEZ; THIAGO HERICK DE SÁ; LEANDRO FÓRNIAS MACHADO DE REZENDE. Why precision medicine is not the best route to a healthier world. Revista de Saúde Pública, v. 52, . (14/25614-4)
MACHADO DE REZENDE, LEANDRO FORNIAS; LEE, DONG HOON; DA COSTA LOUZADA, MARIA LAURA; SONG, MINGYANG; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. Proportion of cancer cases and deaths attributable to lifestyle risk factors in Brazil. CANCER EPIDEMIOLOGY, v. 59, p. 148-157, . (16/21390-0, 14/25614-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
REZENDE, Leandro Fórnias Machado de. Physical Activity and cancer: epidemiological evidence and perspectives for cancer prevention in Brazil. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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