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Assessment of bupivacaine alone or in combination with dexmedetomidine or buprenorphine for sciatic and femoral nerve blocks in cats

Grant number: 15/01712-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2015
Effective date (End): August 31, 2016
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Denise Tabacchi Fantoni
Grantee:Marina Cayetano Evangelista
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Local anesthesia techniques in cats are underestimated and underused in trauma and surgical patients, who might benefit from analgesia provided by regional blocks with minimal adverse effects. Regional anesthesia techniques guided by a electrical nerve locator (ENL) might reduce the required local anesthetic dose to produce a clinically effective blockade. This advantage may be of particular importance in cats, which are more susceptible to toxicity by local anesthetics. Studies that access and validate the peripheral nerve blocks effectiveness in cats are rare. The aim of the present study is to evaluate the spread of local anesthetic and potential complications of sciatic (ScN) and femoral (FN) nerve blocks (ventral approach) guided by ENL, and to determine the magnitude and duration of action of bupivacaine alone or in combination with buprenorphine or dexmedetomidine. The hypothesis is that the volume of 0.1 mL/kg of local anesthetic will produce a reliable injectate spread over the areas of interest without complications when investigated by MRI scan. A second hypothesis is that the combination of bupivacaine-dexmedetomidine or -buprenorphine will enhance and prolong the magnitude and duration of sensorial and motor block when compared with the administration of bupivacaine alone. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
EVANGELISTA, MARINA C.; DE LASSALLE, JULIE; CHEVRIER, CHRISTINE; CARMEL, ERIC N.; FANTONI, DENISE T.; STEAGALL, PAULO V. M.. Distribution of bupivacaine hydrochloride after sciatic and femoral nerve blocks in cats: A magnetic resonance imaging study. Research in Veterinary Science, v. 115, p. 61-65, . (15/01712-0)
EVANGELISTA, M. C.; DOODNAUGHT, G. M.; FANTONI, D. T.; STEAGALL, P. V. M.. Sciatic and femoral nerve blockade using bupivacaine alone, or in combination with dexmedetomidine or buprenorphine in cats. VETERINARY RECORD, v. 180, n. 24, p. 592+, . (15/01712-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
EVANGELISTA, Marina Cayetano. Sciatic and femoral nerve blocks in cats: evaluation of bupivacaine distribution under nuclear magnetic resonance and antinociceptive assessment. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.

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