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Electrospinning by solution of PBAT built nanohidroxiapatita

Grant number: 15/01259-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2015
Effective date (End): January 31, 2016
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Anderson de Oliveira Lobo
Grantee:Aline dos Santos Silva
Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
Associated research grant:11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration, AP.JP


The electrospinning technique by solution have been widely used for the production of nanofiber webs for tissue engineering. The nanohidroxiapatita (nHAp) it is a ceramic biomaterial used for bone reconstruction. The production of nanocomposites based on polymer nanofibers with embedded nHAp aims to improve the mechanical properties associated with bioactivity nHAp, and these interesting properties in the regeneration of bone tissue. The purpose of this article is the study of the physicochemical properties and the production of nanofibers the polymer poly (butylene adipate-co tereftalo (PBAT) with the incorporation of nanohidroxiapatita (nHAp) using the electrospinning method. However, to get to the elaboration of such will be necessary to study the physical and chemical effects of polymer solutions along with the reasons mass / volume nHAp. With this, will be assessed the relationship of organic solvents, liofilizantes agents, solution density, surface tension, temperature and humidity. The process of nHAp dispersion using ultrasonic irradiation are also evaluated such as: time, temperature and inserting liofilizante agent. Electrospinning parameters will be studied, such as applied voltage, distance from the counter electrode and collector type. The webs of nanofibers are characterized using scanning electron microscopy, X-ray diffraction, dispersive X-ray spectroscopy, infrared spectroscopy and analysis by goniometry differential scanning calorimetry. Expected to get a new composite nanobiomaterial to the PBAT / nHAp base that can be used in tissue engineering aimed at bone regeneration. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, ALINE DOS SANTOS; MANZOLLI RODRIGUES, BRUNO VINICIUS; OLIVEIRA, FRANCILIO CARVALHO; CARVALHO, JANCINEIDE OLIVEIRA; REIS DE VASCONCELLOS, LUANA MAROTTA; RIBEIRO DE ARAUJO, JULIANI CAROLINE; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. Characterization and in vitro and in vivo assessment of poly(butylene adipate-co-terephthalate)/nano-hydroxyapatite composites as scaffolds for bone tissue engineering. JOURNAL OF POLYMER RESEARCH, v. 26, n. 2, . (15/01259-3, 16/04618-7, 11/20345-7, 11/17877-7)
RODRIGUES, BRUNO V. M.; SILVA, ALINE S.; MELO, GABRIELA F. S.; VASCONSCELLOS, LUANA M. R.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.. Influence of low contents of superhydrophilic MWCNT on the properties and cell viability of electrospun poly (butylene adipate-co-terephthalate) fibers. Materials Science & Engineering C-Materials for Biological Applications, v. 59, p. 782-791, . (15/01259-3, 15/08523-8, 11/20345-7, 11/17877-7)
ZANIN, HUDSON; MANZOLLI RODRIGUES, BRUNO VINICIUS; RIBEIRO NETO, WILSON ALVES; SUMAN BRETAS, ROSARIO ELIDA; DA-SILVA, NEWTON SOARES; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. High loading of graphene oxide/multi-walled carbon nanotubes into PDLLA: A route towards the design of osteoconductive, bactericidal and non-immunogenic 3D porous scaffolds. Materials Chemistry and Physics, v. 177, p. 56-66, . (11/17877-7, 11/20345-7, 15/01259-3, 13/20054-8, 14/02163-7, 15/08523-8)

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