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Characterization of the skin pigmentation pattern and evaluation of photoprotectors on the reduction of cutaneous hyperchromias

Grant number: 14/26988-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2015
Effective date (End): April 30, 2017
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Patrícia Maria Berardo Gonçalves Maia Campos
Grantee:Ana Paula Martins Martini
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Hyperchromias or hyperpigmentations are disturbs of cutaneous pigmentation that can be caused by aging, pregnancy, endocrinal disturbs, hormonal treatments and sun exposure in different degrees. Among the available treatments in the market, the most used are chemical peeling, laser therapy and lightening cosmetics. In addition, photoprotection is fundamental in prevention of hypercromias as they reduce the stimulus of pigmentation since the synthesis of melanin is stimulated by ultraviolet radiation. Considering the importance of conclusive studies that prove the influence of photoprotection on the reduction of cutaneous hyperchromias, the objective of this study is characterize the pattern of skin pigmentation, develop photoprotective formulations and evaluate the efficacy of these formulations on the reduction of cutaneous hyperchromias. For this purpose, initially, it will be realized the characterization of the pattern of skin pigmentation, development of photoprotective formulations and evaluation of its efficacy ,by biophysical and skin imaging techniques to determinate the skin color, quantification of melanin, detection of cutaneous hyperchromias and quantify the epidermal pigmentation . After that, photoprotective formulations will be developed and its efficacy related to the reduction of hyperchromias will be evaluated by the techniques previously cited. The datas will be analized statistically for discussion and conclusion of the obtained results.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINI, ANA PAULA M.; MERCURIO, DAIANE G.; MAIA CAMPOS, PATRICIA M. B. G.. Assessment of skin pigmentation by confocal microscopy: Influence of solar exposure and protection habits on cutaneous hyperchromias. Journal of Cosmetic Dermatology, v. 16, n. 3, p. 364-369, . (14/26988-5)
MARTINI, ANA PAULA M.; MAIA CAMPOS, PATRICIA M. B. G.. Influence of visible light on cutaneous hyperchromias: Clinical efficacy of broad-spectrum sunscreens. PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, v. 34, n. 4, p. 241-248, . (14/26988-5)
DAIANE GARCIA MERCURIO; LÍVIA SALOMÃO CALIXTO; PATRÍCIA MARIA BERARDO GONÇALVES MAIA CAMPOS. Optimization of cosmetic formulations development using Box-Behnken design with response surface methodology: physical, sensory and moisturizing properties. Brazilian Journal of Pharmaceutical Sciences, v. 56, . (14/26988-5)

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