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Interaction of H2S, NO and CO gaseous systems on in vitro secretion of vasopressin, oxytocin and atrial natriuretic peptide by medial basal hypothalamus and neurohypophysis in response to extracellular hyperosmolality

Grant number: 14/07372-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2015
Effective date (End): February 28, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:José Antunes Rodrigues
Grantee:Ricardo Coletti
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/09799-1 - Energy balance and body fluid homeostasis control: from cells to the physiological systems, AP.TEM


The gases nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) are endogenously produced by hypothalamus, and thus may exert modulatory effects on many hypothalamic nuclei. It has been already demonstrated that, in the condition of extracellular fluid hyperosmolality, NO can inhibit vasopressin (AVP), oxytocin (OT) and atrial natriuretic peptide (ANP) secretion, in addition to water intake. Conversely, CO seems to enhance OT and ANP secretion by inhibiting nitric oxide synthase (NOS) activity, NO-generating enzyme. Furthermore, recent studies of our group show that, during 24-hour water deprivation, exogenous sulfide can reduce thirst, hypothalamic nitrates/nitrites generation (direct metabolites of NO), besides enhancing AVP and OT secretion. In spite of these evidences, so far there are not studies that address altogether the interaction among the three gaseous systems in hypothalamus and neurohypophysis for the fine control of hydroelectrolytic balance. Therefore, we propose an in vitro study aiming to evaluate, during extracellular hyperosmolality, NO, CO and H2S systems behavior and their possible interactions on AVP and OT secretion and central production of ANP by medial basal hypothalamus, and AVP and OT secretion by neurohypophysis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COLETTI, RICARDO; MEDEIROS DE LIMA, JULIANA BEZERRA; VEANHOLI VECHIATO, FERNANDA MARIA; DE OLIVEIRA, FABIANA LUCIO; DEBARBA, LUCAS KNIESS; ALMEIDA-PEREIRA, GISLAINE; KAGOHARA ELIAS, LUCILA LEICO; ANTUNES-RODRIGUES, JOSE. Nitric oxide acutely modulates hypothalamic and neurohypophyseal carbon monoxide and hydrogen sulphide production to control vasopressin, oxytocin and atrial natriuretic peptide release in rats. Journal of Neuroendocrinology, v. 31, n. 2, . (14/07372-3)

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