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Influence of glutamyl-cysteine ligase (catalytic subunit, GCLC, and modifier, GLCM) gene polymorphisms evaluation on lead concentrations in workers exposed to metal

Grant number: 15/01157-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2015
Effective date (End): December 31, 2015
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Gustavo Rafael Mazzaron Barcelos
Grantee:Bruno Limonti Cano Luiz
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/06033-8 - Combining omics tools for predicting multivariate models in populations exposed to toxic metals, AP.JP


There is a wide variation in levels of biomarkers and toxicity of lead (Pb), despite similar levels of exposure and this is hypothetically related genetic differences in the enzymes that metabolize the metal. However, very little is known about the genetic effects on metabolism and toxicity induced by Pb. Therefore, aims of the present study is to evaluate metal-gene interactions in workers of automotive batteries plants, exposed to Pb. So, concentrations of Pb in blood will be determined by the use of a inductively coupled plasma mass spectrometer. Evaluation of the polymorphisms glutamyl-cysteine ligase (catalytic subunit, GCLC, and modifier, GLCM) will be performed by the TaqMan assays (RT-qPCR) aiming to assess the genetic effects on the metabolism of the metal. Thus, it is expected that the results obtained here will assist for a better understanding of the interactions between the metal and these genetic variants, a survey line in the country incipient but very promising called "gene-environment interactions."

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES, WILLIAN ROBERT; DEVOZ, PAULA PICOLI; CANO LUIZ, BRUNO LIMONTI; GROTTO, DENISE; BATISTA, BRUNO LEMOS; BARBOSA, JR., FERNANDO; MAZZARON BARCELOS, GUSTAVO RAFAEL. Polymorphisms of genes related to metabolism of lead (Pb) are associated with the metal body burden and with biomarkers of oxidative stress. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v. 836, n. B, SI, p. 42-46, . (13/06033-8, 14/24981-3, 15/07277-3, 15/04786-4, 15/01157-6)

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