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Grant number: 14/20932-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2015
Effective date (End): January 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Marcelo José Pena Ferreira
Grantee:Cinthia Indy Tamayose
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Asteraceae is one the world's largest families of Eudicots comprising several species used for economic and medicinal purposes, characterized by the production of important bioactive metabolites. The aim of this project is to explore the metabolome of non-studied Moquiniastrum and Richterago species as a source of new bioactive compounds. The crude extracts from plants will be prepared, fractionated and subjected to bioassays (antifungal, antiradical, anti-inflammatory, antiviral, antitumoral, antileishmanial and allelopathic activities). The identification of compounds will be carried out through the dereplication methods. Samples showing non-characterized natural products will be purified and the new compounds will be identified through spectroscopic methods and assessed in biological assays. Recently, the phylogeny of the Gochnatieae showed Moquiniastrum and Richterago as sister groups, however with a lower statistic support. Therefore, the data obtained from the metabolome of the species will be utilized as chemotaxonomic characters to corroborate with the phylogeny of the group, in an integrative taxonomic approach of the Gochnatioideae. The project will contribute to the expansion of knowledge about the chemical diversity and biological potential from Brazilian species of Moquiniastrum and Richterago.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TAMAYOSE, C. I.; TORRES, P. B.; ROQUE, N.; FERREIRA, M. J. P.. HIV-1 reverse transcriptase inhibitory activity of flavones and chlorogenic acid derivatives from Moquiniastrum floribundum (Asteraceae). SOUTH AFRICAN JOURNAL OF BOTANY, v. 123, p. 142-146, . (14/20932-8, 14/21593-2)
INDY TAMAYOSE, CINTHIA; DOS SANTOS, EVELYNE A.; ROQUE, NADIA; COSTA-LOTUFO, LETICIA V.; PENA FERREIRA, MARCELO J.. Caffeoylquinic Acids: Separation Method, Antiradical Properties and Cytotoxicity. CHEMISTRY & BIODIVERSITY, v. 16, n. 7, . (14/20932-8, 15/17177-6, 14/21593-2)
DOS SANTOS JUNIOR, ADEILSO BISPO; TAMAYOSE, CINTHIA I.; FERREIRA, MARCELO J. P.; BELCHOR, MARIANA N.; COSTA, CAROLINE R. C.; DE OLIVEIRA, MARCOS ANTONIO; TOYAMA, MARCOS HIKARI. Bioaffinity Fishing Procedure Using Secretory Phospholipase A2 for Screening for Bioactive Components: Modulation of Pharmacological Effect Induced by sPLA2 from Crotalus durissus terrificus by Hispidulin from Moquiniastrum floribundum. Molecules, v. 25, n. 2, . (17/20291-0, 14/21593-2, 17/19942-7, 14/20932-8)
BITTENCOURT RODRIGUES, CAROLINE FABRI; PENA FERREIRA, MARCELO JOSE; BELCHOR, MARIANA NOVO; COSTA, CAROLINE R. C.; NOVAES, DANIELLE P.; DOS SANTOS JUNIOR, ADEILSO BISPO; TAMAYOSE, CINTHIA I.; TERASHIMA PINHO, MARCUS VINICIUS; DE OLIVEIRA, MARCOS ANTONIO; TOYAMA, MARCOS HIKARI. Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2. MARINE DRUGS, v. 17, n. 7, . (17/20291-0, 14/20932-8, 14/21593-2, 13/10938-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TAMAYOSE, Cinthia Indy. Moquiniastrum e Richterago (Asteraceae): Phytochemical,chemosystematic and biological activities. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.

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