PHYTOCHEMISTRY, CHEMOSYSTEMATIC STUDY AND BIOLOGICAL ACTIVITIES OF Moquiniastrum AND Richterago SPECIES

Abstract

Asteraceae is one the world's largest families of Eudicots comprising several species used for economic and medicinal purposes, characterized by the production of important bioactive metabolites. The aim of this project is to explore the metabolome of non-studied Moquiniastrum and Richterago species as a source of new bioactive compounds. The crude extracts from plants will be prepared, fractionated and subjected to bioassays (antifungal, antiradical, anti-inflammatory, antiviral, antitumoral, antileishmanial and allelopathic activities). The identification of compounds will be carried out through the dereplication methods. Samples showing non-characterized natural products will be purified and the new compounds will be identified through spectroscopic methods and assessed in biological assays. Recently, the phylogeny of the Gochnatieae showed Moquiniastrum and Richterago as sister groups, however with a lower statistic support. Therefore, the data obtained from the metabolome of the species will be utilized as chemotaxonomic characters to corroborate with the phylogeny of the group, in an integrative taxonomic approach of the Gochnatioideae. The project will contribute to the expansion of knowledge about the chemical diversity and biological potential from Brazilian species of Moquiniastrum and Richterago.