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Determination of gene clusters involved in the biosynthetic pathway for phenazine antibiotic and assembly of biosynthetic pathways correlated in a new species of Streptomyces (CCMA/Caat52) isolated from the Caatinga biome of Brazil

Grant number: 14/24556-0
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): May 01, 2015
Effective date (End): April 30, 2016
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal researcher:Itamar Soares de Melo
Grantee:Suikinai Nobre Santos
Supervisor abroad: Paul Frederick Long
Home Institution: Embrapa Meio-Ambiente. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). Jaguariúna , SP, Brazil
Research place: King's College London, England  
Associated to the scholarship:13/16037-0 - Isolation and characterization of genes correlated to biosynthesis of antitumor molecules in Streptomyces sp., BP.PD


Complex polyketides are microbial natural products (including clinically-useful medicines) whose chemical structures correlate with the sequence of the modular enzymes responsible for their biosynthesis. This unique paradigm means that the structure of the gene can be inferred from the chemical structure of the molecule, and (with less certainty) the reverse is true. Now, genome-scale sequencing of actinomycetes has revealed untapped chemical diversity in culturable Streptomycetes: there are many biosynthetic clusters present but most are cryptic (silent). Expression of biosynthetic genes is now a severe bottleneck in trying to develop a genuine synthetic biology of natural products, in which PKSs are designed and fabricated to order to produce a specificed target molecule. According to preliminary studies of the analysis of the genome of strain model in this study, CCMA/Caat52 is a new species of Streptomyces and poor knowledge of gene blocks biosynthetic pathways responsible for the production of phenazinas by actinobacteria, then this project aims to research on the discovery and determination of genes (PKS and NRPS) responsible for producing biosynthetic pathways of phenazinas. The information and training will be very useful in the search for consolidation line of research in microbial bioprospecting using the discovery of genes related to the biosynthesis of secondary metabolites and sequencing of the entire genome of Streptomyces sp. Environmental Microbiology Laboratory at Embrapa Environment. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VARGAS HOYOS, HAROLD ALEXANDER; SANTOS, SUIKINAI NOBRE; PADILLA, GABRIEL; MELO, ITAMAR SOARES. Genome Sequence of Streptomyces cavourensis 1AS2a, a Rhizobacterium Isolated from the Brazilian Cerrado Biome. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 8, n. 18 MAY 2019. Web of Science Citations: 0.
KAVAMURA, VANESSA NESSNER; SANTOS, SUIKINAI NOBRE; TAKETANI, RODRIGO GOUVEA; FIGUEIREDO VASCONCELLOS, RAFAEL LEANDRO; MELO, ITAMAR SOARES. Draft Genome Sequence of Plant Growth-Promoting Drought-Tolerant Bacillus sp. Strain CMAA 1363 Isolated from the Brazilian Caatinga Biome. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 5, n. 5 FEB 2017. Web of Science Citations: 0.
SANTOS, SUIKINAI NOBRE; GACESA, RANKO; TAKETANI, RODRIGO GOUVEA; LONG, PAUL F.; MELO, ITAMAR SOARES. Genome Sequence of Streptomyces caatingaensis CMAA 1322, a New Abiotic Stress-Tolerant Actinomycete Isolated from Dried Lake Bed Sediment in the Brazilian Caatinga Biome. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 3, n. 5 SEP-OCT 2015. Web of Science Citations: 0.

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