Scholarship 14/22967-3 - Transaminases, Biocatálise - BV FAPESP
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Piperidine and Pyrrolidine Alkaloids Synthesis in Multi-enzymatic systems

Grant number: 14/22967-3
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Start date until: March 01, 2015
End date until: February 28, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Anita Jocelyne Marsaioli
Grantee:Bruna Zucoloto da Costa
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):15/22513-5 - Biocatalytic processes involving transaminases and imine reductases for the synthesis of ant venom alkaloids., BE.EP.PD

Abstract

Piperidine and pyrrolidine alkaloids are important natural products ubiquitous in plants and insects. These compounds are quite important and well described in the literature, mainly due to their biological activities. However, the importance of absolute configuration to these activities has been underexploited due to the scarcity of pure enantiomers either in nature or synthetic samples. Therefore, synthesize these alkaloids in an enantiopure or enriched form is a key aspect to future applications of these alkaloids and derivatives. In this context, this project aims the use of an enzymatic cascade reaction, involving a transaminase (TA) and an imine reductase (IRed), for the production of 2,6-alkyl piperidines and 2,5-alkyl pyrrolidines from diketones.

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA, JONAS HENRIQUE; DA COSTA, BRUNA ZUCOLOTO; DE ANGELIS, DERLENE ATTILI; MARSAIOLI, ANITA JOCELYNE. Monoamine oxidase and transaminase screening: biotransformation of 2-methyl-6-alkylpiperidines by Neopestalotiopsis sp CBMAI 2030. Applied Microbiology and Biotechnology, v. 101, n. 15, p. 6061-6070, . (14/22967-3)
COSTA, BRUNA Z.; GALMAN, JAMES L.; SLABU, IUSTINA; FRANCE, SCOTT P.; MARSAIOLI, ANITA J.; TURNER, NICHOLAS J.. Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts. CHEMCATCHEM, v. 10, n. 20, p. 4733-4738, . (15/22513-5, 14/22967-3, 14/50249-8)

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