Scholarship 14/07241-6 - Medula óssea, Reparação periodontal - BV FAPESP
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Microtomographic analyze of bone marrow aspirate concentrate in fenestration periodontal regeneration in rats

Grant number: 14/07241-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date until: February 01, 2015
End date until: December 31, 2015
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Daniela Bazan Palioto Bulle
Grantee:Lara Martins de Mello Pires
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The objective of this study is to evaluate the regenerative potential of bone marrow aspirate concentrate (BMAC) in periodontal fenestration defects surgically created on one side of the mandible of rats . Animals (72 rats) will be randomly divided into 3 groups: 1) Group C (Control): the defect will be filled with blood clot; 2) PGA Group (Propylene Glycol Alginate): the defect will be filled with APG, 3) Group ACMO - PGA: the defect will be filled with PGA associated with BMAC. The animals will be divided into 3 subgroups for euthanasia at 15, 30 and 60 days postoperatively. The hemimandibule is fixed in 4% formaldehyde for microtomographic analysis in order to assess the linear measures coronal, transaxial and sagital axis and the linear definition of the original osseous defect in the mesio- distal direction and the linear extent of the bone defect original without new bone by Data Viewer program. Volumetric analyzes will be conducted to measure the volume of newly formed alveolar bone from the measurement of the total area of the bone defect area and new bone formation using 3D analysis program (AWC v.1.10) . The data will be statistically analyzed, adopting a significance level of 5%.

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