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Immunological study of the interaction between dendritic cells an biopolymeric nanofibers

Grant number: 15/00771-2
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 01, 2015
Effective date (End): December 23, 2015
Field of knowledge:Engineering - Biomedical Engineering - Medical Engineering
Principal researcher:Luiz Henrique Capparelli Mattoso
Grantee:Rafaella Takehara Paschoalin
Supervisor abroad: Martin Zenke
Home Institution: Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
Research place: RWTH Aachen University, Germany  
Associated to the scholarship:13/03474-3 - Development of polymeric nanostructures for application in tissue engineering, BP.DR


Biomaterials are used in many medical applications, ranging from scaffolds for tissue regeneration to drug delivery systems. However, biomaterials often cause inflammatory reactions because they profoundly alter the homeostasis of host immune cells, such as dendritic cells (DCs). Thus, there is a major need to understand how biomaterials affect the immune function of DCs. In this project, we will analyse the chemical and physical influence of poly(lactic acid) (PLA) and PLA/polyethylene glycol (PLA/PEG) blends on functional properties in DCs. Our findings should be useful for designing structures of scaffolds with more preferable biocompatible properties. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PASCHOALIN, RAFAELLA T.; TRALDI, BRUNA; AYDIN, GUELCAN; OLIVEIRA, JULIANO E.; MITTEN, STEPHAN; MATTOSO, LUIZ H. C.; ZENKE, MARTIN; SECHI, ANTONIO. Solution blow spinning fibres: New immunologically inert substrates for the analysis of cell adhesion and motility. Acta Biomaterialia, v. 51, p. 161-174, . (13/03474-3, 15/00771-2)

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