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Mechanisms of antioxidante defense in the state of induced post-hipoxia in Phrynops geoffroanus (Testudines: Chelidae)

Grant number: 14/22398-9
Support type:Scholarships in Brazil - Master
Effective date (Start): January 01, 2015
Effective date (End): February 29, 2016
Field of knowledge:Biological Sciences - Zoology - Applied Zoology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Claudia Regina Bonini Domingos
Grantee:Nathalia Rossigalli Alves Costa
Home Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil


During the course of evolution, some turtles evolved mechanisms that allow them to deal with situations of oxygen deprivation and reperfusion, like the decreased production of Reactive Oxygen Species (ROS) and a high antioxidant capacity. Phrynops geoffroanus (Testudines: Chelidae) comprises a group of reptiles that easily survives at anoxic environments, representing an excellent model for studies related to the physiological and biochemical mechanisms involved in resistance to oxidative stress and cell damage, which may also be related to the longevity of these animals. Therefore, this study aims to understand the mechanisms of antioxidant defense that operate in the post-state of induced hypoxia in Phrynops geoffroanus, trying to evaluate the activity of the main antioxidant enzymes, as well as cellular damage in the brain, heart, liver and pancreas after reperfusion. The experiments will be conducted at normoxic and induced hypoxic situation. We believe that rates of enzymatic activity will be greater in tissues of the animals at hypoxic period. In relation to cell damage we expected that, due to P. geoffroanus adaptations, which allow their survivor at environments with low oxygen, cell damage will be low or even absent. The results obtained in this study may not only elucidate issues of conservation of a species often neglected, but also contribute to a better understanding of the life history, biochemistry and cell biology in these animals, as well as understand the different effects and repair mechanisms of oxidative stress. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA, N. R. A.; VENANCIO, L. P. R.; BONINI-DOMINGOS, C. R. Mechanisms of antioxidant defense in the state of post-hypoxia in Phrynops geoffroanus (Testudines: Chelidae). Genetics and Molecular Research, v. 15, n. 4 2016. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
COSTA, Nathalia Rossigalli Alves. Mechanisms of antioxidante defense in the state of post-hipoxia in Phrynops geoffroanus (Testudines:Chelidae). 2016. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências Letras e Ciências Exatas. São José do Rio Preto São José do Rio Preto.

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