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Block copolymers of polyphosphoesters and poly(L-lactic acid) for biomedical applications

Grant number: 14/24383-9
Support type:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): March 02, 2015
Effective date (End): September 01, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Maria Isabel Felisberti
Grantee:Lívia Mesquita Dias Loiola
Supervisor abroad: Frederik Roman Wurm
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: Max Planck Society, Mainz, Germany  
Associated to the scholarship:12/24821-0 - Biocompatible composites based on amphiphilic copolymers and hydroxyapatite, BP.DD


Poly(L-lactic acid) (PLLA) is widely used in polymer-based biomaterials due to its biodegradability and biocompatibility. However, PLLA present some limitations regard to its hydrophobic surface and high crystallinity degree. Polyphosphoesters (PPE) present a structural diversity by varying the chemical groups attached to the phosphorus center, which allows the synthesis of hydrophilic segments. Copolymerization of PLLA with hydrophilic PPE blocks enables the preparation of PLLA-PPE-PLLA biocompatible amphiphilic copolymers with favorable biocompatibility, biodegradability, and controllable hydrophilicity, i.e. suitable candidates for biomedical applications. (AU)

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