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Preparation and evaluation of monolithic silica-based modified with poly (dimethyl siloxane) (PDMS) for use in capillary liquid chromatography

Grant number: 14/21866-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): December 01, 2014
Effective date (End): November 30, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Carla Beatriz Grespan Bottoli
Grantee:Fabiane Pires
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The aim of this project is to prepare, characterize and evaluate monolithic silica-based capillary columns, focusing on the process of immobilization of the polymer poly (dimethylsiloxane) (PDMS) on the silica monolith for application in capillary liquid chromatography. The preparation of monoliths will use the sol-gel process and the immobilization process of the polymer PDMS will be studied to optimize the conditions of solubilization, as well as the steps involved in the thermal immobilization: time, temperature and immobilization cycles, besides evaluation of the best extraction conditi ons. The characterization and evaluation of the monolithic columns will use scanning electron microscopy and several chromatographic parameters: retention factor (k), column efficiency calculated at half peak height (N), asymmetry factor at 10% of the peak height (As) and separation factor for adjacent peaks in test mixtures. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PIRES, FABIANE; BAUTISTA OTALORA, JULIE ALEXANDRA; GRESPAN BOTTOLI, CARLA BEATRIZ. New stationary phase for capillary liquid chromatography based on polydimethylsiloxane immobilized onto a Monolithic Silica Support. SEPARATION SCIENCE PLUS, v. 1, n. 5, p. 343-350, . (14/21866-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PIRES, Fabiane. Preparation and evaluation of monolithic capillary columns based on silica modified with polydimethylsiloxane (PDMS) for use in capillary liquid chromatography. 2017. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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