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Use of direct immunofluorescence as a diagnostic adjunct test in patients presentin oral lichen planus

Grant number: 14/14576-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2014
Effective date (End): November 30, 2015
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Ana Carolina Fragoso Motta
Grantee:Yasmin Yamanaka
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Oral lichen planus (OLP) is a chronic inflammatory disease affecting women with a frequency of 0.1 to 4% in a general population, and of unknown cause. The diagnosis is established based on the clinical and histopathological findings, however direct immunofluorescence can be help the diagnosis specially for differentiating LPO of other autoimune diseases. Thus, this study aims to determine if direct immunofluorescênce can be used as an adjuvant test for the diagnosis of LPO. Patients referred to School of Dentistry of Ribeirão Preto and School od Dentistry (Sao Paulo Campus)to evaluate oral lesions, during the period of 2014 to 2015, who fill the inclusion criteria will participate of this study. There will be four study groups: Group OLP - 20 patients presenting OLP; Group OLL - 20 patients presenting OLL; Positive control group - 20 patients presenting pemphigus vulgaris; and Negative control group - 20 patients presenting inflammatory fibrous hyperplasia. After the clinical examination, incisional biopsy and histopathological analysis will be made for defining the diagnosis. Additionally, direct immunofluorescence will be made in order to characterize the LPO lesions. This study will be submmited to approval by the Institutional Review Board of School of Dentistry of Ribeirão Preto, and all patients should provide written informed consent in accordance with the Declaration of Helsinki. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZUCOLOTO, MIRIANE LUCINDO; WARIKODA SHIBAKURA, MATHEUS EIJI; PAVANIN, JEFFERSON VERONEZI; GARCIA, FERNANDA TEIXEIRA; DA SILVA SANTOS, PAULO SERGIO; MACIEL, ALOIZIO PREMOLI; GALLO, CAMILA DE BARROS; SOUZA, NATHALIA VILELA; ALENCAR RAMOS INNOCENTINI, LARA MARIA; MARTINS HUMBERTO, JANAINA SILVA; et al. Severity of oral lichen planus and oral lichenoid lesions is associated with anxiety. CLINICAL ORAL INVESTIGATIONS, v. 23, n. 12, p. 4441-4448, . (14/11883-3, 14/14576-4)
YAMANAKA, YASMIN; YAMASHITA, MAURICIO; INNOCENTINI, LARA M. A.; MACEDO, LEANDRO D.; CHAHUD, FERNANDO; RIBEIRO-SILVA, ALFREDO; ROSELINO, ANA MARIA; ROCHA, MARIA JOSE A.; MOTTA, ANA CAROLINA. Direct Immunofluorescence as a Helpful Tool for the Differential Diagnosis of Oral Lichen Planus and Oral Lichenoid Lesions. AMERICAN JOURNAL OF DERMATOPATHOLOGY, v. 40, n. 7, p. 491-497, . (14/14576-4, 14/11883-3)

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