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Application of diazonium salts chemistry in structural modification of BODIPY fluorophores

Grant number: 14/18973-8
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): December 01, 2014
Effective date (End): July 31, 2016
Field of knowledge:Health Sciences - Pharmacy
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Flavio da Silva Emery
Grantee:Shaiani Maria Gil de Melo
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The BODIPYs (boron dypirromethene) are fluorescent compounds with a wide range of technological applications. These compounds have been highlighted in the literature in the photochemical and synthetic area. However, the chemical reactivity of these fluorophores are not fully understood. Therefore, we will study chemical reactivity of BODIPYs and develop a library of new fluorescent compounds. In this regard, we will use the chemistry of diazonium salts applied to BODIPYs, exploring a number of perspectives for structural diversification of these fluorophores. This strategy has not been applied to BODIPYs yet and has great potential for the development of compounds for chemical, biochemical and biological interest. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AMORIM, VANESSA G.; MELO, SHAIANI M. G.; LEITE, RUAN F.; COUTINHO, PAULO ARTHUR; DA SILVA, SARAH M. P.; DA SILVA, ANDRE R.; AMORIM, FERNANDA G.; PIRES, RITA G. W.; COITINHO, JULIANA B.; EMERY, FLAVIO S.; et al. Synthesis and characterization of two novel red-shifted isothiocyanate BODIPYs and their application in protein conjugation. DYES AND PIGMENTS, v. 182, . (14/18973-8, 13/24408-9, 11/23342-9)
REZENDE, LUCAS C. D.; MELO, SHAIANI M. G.; BOODTS, STIJN; VERBELEN, BRAM; EMERY, FLAVIO S.; DEHAEN, WIM. Thiocyanation of 3-substituted and 3,5-disubstituted BODIPYs and its application for the synthesis of new fluorescent sensors. DYES AND PIGMENTS, v. 154, p. 155-163, . (14/18973-8, 11/23342-9, 14/22451-7)
GIL DE MELO, SHAIANI MARIA; DIAS DE REZENDE, LUCAS CUNHA; PETRILLI, RAQUEL; VIANNA LOPEZ, RENATA FONSECA; GOULART, MARILIA O. F.; EMERY, FLAVIO DA SILVA. Nitrosation of BODIPY dyes and their applications in the development of thiol sensors. DYES AND PIGMENTS, v. 173, . (13/50677-7, 14/18973-8, 11/23342-9, 14/22451-7, 17/21146-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MELO, Shaiani Maria Gil de. Diazonium salts chemistry applied to BODIPY fluorophores. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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