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Histological and histomorphometric evaluation of chitosan, collagen and hydroxyapatite composites as bone graft substitute in a sheep tibial defect

Grant number: 14/16670-8
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): November 01, 2014
Effective date (End): May 31, 2016
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:André Luis do Valle de Zoppa
Grantee:Nicole Fidalgo Paretsis
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Bone defects are commonly found in veterinary medicine through different illnesses such as trauma or metabolic changes. Often, intervention is required during tissue repair. Biomaterials have been developed to this objective. Evaluating cell behavior with the biomaterial in vivo is essential. Studying morphological and functional unit of tissue, it is possible to evaluate the quantity and the quality of new formed tissue. Currently in orthopedic studies, sheep are being used as animal model for implant biomaterial reserach. From bone defects in sheep experimentally performed, will be implanted biomaterials based on chitosan, hydroxyapatite and collagen. After 60 days, by biopsy, will be performed histomorphometry and transmission microscopy. The newly formed tissue will be described, evaluated and compared. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PARETSIS, Nicole Fidalgo. Histological and histomorphometric evaluation of the bone regeneration with the use of chitosan, collagen and hydroxyapatite composites as a bone substitute in bone defect induced in the tibia of sheep. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.

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