Advanced search
Start date

Study aiming to the convergent total synthesis of the aporphine alkaloid (R)-(-)-apomorphine

Grant number: 14/09180-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): November 01, 2014
Effective date (End): April 30, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Cristiano Raminelli
Grantee:Ana Carolina de Avelar Muraca
Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil


Due to the considerable importance of 2-(trimethylsilyl)aryl triflates in the current context of the benzyne chemistry, we intend to develop the convergent total synthesis of the aporphine alkaloid (R)-(-)-apomorphine, which is used as medicine in the therapy of Parkinson's disease and in the treatment of erectile dysfunction, employing approach that presents in the key step [4+2] cycloaddition reaction followed by a [1,3] sigmatropic rearrangement of hydrogen between 1-methylene-1,2,3,4-tetrahydroisoquinoline and aryne, formed from its corresponding 2-(trimethylsilyl)aryl triflate, under relatively mild reaction conditions. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: