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Multilayer-omics analysis of cancer cachexia: integrative approach to identify biomarkers and drug targets

Grant number: 14/13941-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2014
Effective date (End): April 23, 2018
Field of knowledge:Biological Sciences - Morphology - Histology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Robson Francisco Carvalho
Grantee:Geysson Javier Fernandez Garcia
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):16/08294-1 - Molecular mechanisms underlying TNF-induced and repression gene expression in cachexia, BE.EP.DR

Abstract

Cancer cachexia is a syndrome characterized by the severe wasting of skeletal muscle tissue; that is estimated to affect more than 50% of all cancer patients and results in lower quality of life due to compromised fatigue, weakness, immune function, insulin resistance and poor tolerance and response to chemotherapy. Remarkably, approximately 30% of cancer-related deaths are estimated as a result of cachexia. There is no effective targeted therapy for muscle wasting in cancer cachexia. The complexity of mechanisms controlling gene expression in this process suggests the involvement of additional regulatory molecular interactions, in this way Omic studies have helped clarify the impact of regulatory elements on disease. The feasibility of genome-wide analysis of Omics marks at nucleotide resolution using Next Generation Sequencing has already been demonstrated in the ENCODE projects, as well as the TCGA consortium. Considering this, our hypothesis is that comparison of muscles omics profiles from healthy and cancer cachexia will reveal disease novel specific signatures and a better understanding of the cellular signaling mechanisms and gene regulation in muscle, which will lead to the identification of candidate genes, involved in the pathogenesis, and may be helpful in finding biomarkers and drug targets. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PACCIELLI FREIRE, PAULA; JAVIER FERNANDEZ, GEYSSON; DE MORAES, DIOGO; SANTILONI CURY, SARAH; DAL PAI-SILVA, MAELI; DOS REIS, PATRICIA PINTOR; ROGATTO, SILVIA REGINA; CARVALHO, ROBSON FRANCISCO. The expression landscape of cachexia-inducing factors in human cancers. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, . (13/50343-1, 18/19695-2, 12/13961-6, 14/13941-0)
FERNANDEZ, GEYSSON JAVIER; FERREIRA, JUAREZ HENRIQUE; VECHETTI JR, IVAN JOSE; DE MORAES, LEONARDO NAZARIO; CURY, SARAH SANTILONI; FREIRE, PAULA PACCIELLI; GUTIERREZ, JAYSON; FERRETTI, RENATO; DAL-PAI-SILVA, MAELI; ROGATTO, SILVIA REGINA; et al. MicroRNA-mRNA Co-sequencing Identifies Transcriptional and Post-transcriptional Regulatory Networks Underlying Muscle Wasting in Cancer Cachexia. FRONTIERS IN GENETICS, v. 11, . (13/02005-0, 12/13961-6, 13/50343-1, 16/08294-1, 14/13941-0, 11/16282-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GARCIA, Geysson Javier Fernandez. Gene regulation strategies underlying skeletal muscle atrophy in cancer cachexia. 2018. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.