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Subproteome of fraction I from the venom of Tityus serrulatus scorpion by mass spectrometry

Grant number: 14/22959-0
Support Opportunities:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): January 02, 2015
Effective date (End): March 01, 2015
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Eliane Candiani Arantes Braga
Grantee:Heloisa Tavoni Longhim Peccin
Supervisor: Edwin De Pauw
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: Université de Liège (ULg), Belgium  
Associated to the scholarship:14/07824-1 - Structural and functional characterization of toxins with biotechnological interest present in fraction I from Tityus serrulatus venom, BP.IC


Tityus serrulatus (Ts) is considered the most common and dangerous species in Brazil, being responsible for the greatest number of accidents. Its venom is composed of many substances such as insoluble mucus, oligopeptides, mucopolysaccharides, nucleotides, low molecular, weight molecules (serotonin or histamine), protease inhibitors, histamine releasers, amino acids and other organic compounds, enzymes and neurotoxins. The study of venom components can help to elucidate the systems involved in envenoming and to identify molecules that can be used as molecular tools and/or drugs with therapeutic action. Protein separation techniques, such as high performance liquid chromatography (HPLC), and mass spectrometry associated with soft ionization mechanisms, allowed a more detailed proteomic analysis of animal venoms. Therefore, this project aims to apply mass spectrometry techniques for structural analysis of the components present in fraction I from Tityus serrulatus venom. Many components of this fraction were isolated by different chromatographic procedures and their structural characterizations will indicate the toxin class to which they belong and if they present potential biotechnological applications. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AMORIM, FERNANDA GOBBI; LONGHIM, HELOISA TAVONI; COLOGNA, CAMILA TAKENO; DEGUELDRE, MICHEL; DE PAUW, EDWIN; QUINTON, LOIC; ARANTES, ELIANE CANDIANI. Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, . (14/07824-1, 15/17466-8, 12/14996-8, 13/26083-0, 11/23236-4, 14/22959-0, 13/26200-6)

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