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Does Caveolin-1 (Cav-1) modulate arrhythmogenecity by regulating cSrc tyrosine kinase and cardiac gap junction homeostasis? Role of thyroid hormone

Grant number: 14/21464-8
Support Opportunities:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): March 01, 2015
Effective date (End): December 15, 2015
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Maria Luiza de Morais Barreto de Chaves
Grantee:Ivson Bezerra da Silva
Supervisor: Marcelo G. Bonini
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Illinois at Chicago (UIC), United States  
Associated to the scholarship:13/04703-6 - Subcellular renin angiotensin system as mediator of the cardioprotective effector of thyroid hormone in ischemia reperfusion model, BP.DD

Abstract

The heart corresponds to main target of TH and many of the classic signs and symptoms of hyperthyroidism are the cardiac and hemodynamic manifestations which include heart rhythm disorders. The present study has as aim to define the role of Caveolin-1 (Cav-1) depletion and oxidative stress in the pro-arrhythmic effects of hyperthyroidism. We will define whether Cav-1 deletion in mice leads to arrhythmias, will define in vitro whether cardiac myocytes exposed to high levels of thyroid hormone lose Cav-1 expression and by what mechanisms and integrate both approaches by examining whether intervening on the Cav-1/c-Src pathway can preserve adequate cardiac function in mice despite of elevated thyroid hormone levels. This last piece of the work being of very high clinical relevance. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MCCAULEY, MARK D.; HONG, LIANG; SRIDHAR, ARVIND; MENON, AMBILI; PERIKE, SRIKANTH; ZHANG, MEIHONG; DA SILVA, IVSON BEZERRA; YAN, JIAJIE; BONINI, MARCELO G.; AI, XUN; et al. Ion Channel and Structural Remodeling in Obesity-Mediated Atrial Fibrillation. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, v. 13, n. 8, . (14/21464-8)

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