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Evaluation of the expression of microRNAs associated with ROCK kinases and their role in the invasion process in osteosarcoma

Grant number: 14/07117-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): November 01, 2014
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Luiz Gonzaga Tone
Grantee:Lara Elis Alberici Delsin
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Osteosarcoma is the most common pediatric primary bone cancer. The treatment is based on surgical resection, followed by neoadjuvant and adjuvant multimodal therapy. However, around 80% of patients that present metastatic events at diagnosis have a poor overall survival rates. Lungs and other bones are the main affected organs and there still are no standard treatment for these cases. Therefore, a better understanding of metastatic process has become primordial, as well as the search for new therapeutic targets. The major pathway related with the invasion and migration by neoplastic cells involves the Rho family GTPases, whose principal effectors are the ROCK1 and ROCK2 kinases. These proteins are responsible for cell migration through cytoskeleton control and have been reported to be overexpressed in a wide range of neoplasms, including osteosarcoma. Moreover, high levels of ROCKs have been associated with poor prognosis. Recently, studies have pointed microRNAs deregulation in tumorigenesis process. The hypoexpression of some microRNAs has been related with ROCK kinases hyperexpression, therefore they may also be involved in the metastatic process. Thus, the aim of this project is analyze ROCKs kinases and microRNAs expressions in tumor samples and perform functional assays after induction or repression of associated microRNAs. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROBERTO, GABRIELA MOLINARI; VIEIRA, GABRIELA MACIEL; ALBERICI DELSIN, LARA ELIS; SILVA, MARCELA DE OLIVEIRA; HAKIME, RODRIGO GUEDES; ENGEL, EDGARD EDUARD; SCRIDELI, CARLOS ALBERTO; TONE, LUIZ GONZAGA; BRASSESCO, MARIA SOL. MiR-708-5p is inversely associated with EWS/FLI1 Ewing sarcoma but does not represent a prognostic predictor. CANCER GENETICS, v. 230, p. 21-27, . (14/07117-3, 14/03877-3, 15/00524-5, 14/07118-0)
DELSIN, L. E. A.; ROBERTO, G. M.; FEDATTO, P. F.; ENGEL, E. E.; SCRIDELI, C. A.; TONE, L. G.; BRASSESCO, M. S.. Downregulated Adhesion-Associated microRNAs as Prognostic Predictors in Childhood Osteosarcoma. Pathology & Oncology Research, v. 25, n. 1, p. 11-20, . (14/07117-3, 14/03877-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
DELSIN, Lara Elis Alberici. Evaluation of the expression of microRNAs associated with ROCK kinases and their role in the invasion process in osteosarcoma. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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