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Effect of letrozole in the hypothalamus and gonads of the agoutis during the stages of sexual development of male and female

Grant number: 13/22708-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2014
Effective date (End): June 30, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Antônio Chaves de Assis Neto
Grantee:Maria Angélica Machado Arroyo
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Due to the ease of reproduction in captivity and the potential for creating zootechnical the Spix's yellow-toothed cavy (Galea spixii) has been the subject of several studies. Therefore, it is also important to understand the molecular and enzymatic mechanisms linked to its reproduction. The enzyme aromatase cytochrome P450 plays an important role in the conversion of estrogens from androgens. The gene which controls the conversion is the CYP19, which is also found in the brain and gonads of species and are linked to the areas of the brain aromatization, dimorphism and sexual behavior. In this context, this project aims to establish the molecular basis for understanding the behavior steroidogenic gonads and the role of aromatization in the brain of Spix's yellow-toothed cavy. For this study will be analyzed two groups of animals in the following stages of sexual development: impubertal, pre-pubertal, pubertal and adults, and the second experimental group will be administered with an aromatase inhibitor (letrozole). For both, will be collected the hypothalamic regions, testes, ovaries and adrenal glands at different stages of sexual development. The tissues will be analyzed for their behavior hystometric, expression levels of P450 aromatase and gene expression of CYP19. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARROYO, MARIA ANGELICA MACHADO; SANTOS, PAULO RAMOS DA SILVA; DE OLIVEIRA, MOACIR FRANCO; NETO, ANTONIO CHAVES DE ASSIS. Prolonged use of letrozole causes morphological changes on gonads in Galea spixii. ANIMAL REPRODUCTION, v. 18, n. 2 2021. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ARROYO, Maria Angélica Machado. Effect of letrozole in hypothalamus and gonads of spixs yellow-toothed cavy during sexual development. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.

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