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Re-mineralization potential of an experimental multi-mode adhesive system containing bio-mimetic analogs and bioactive calcium phosphates

Grant number: 14/11301-4
Support type:Scholarships abroad - Research
Effective date (Start): February 01, 2015
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal researcher:Mário Alexandre Coelho Sinhoreti
Grantee:Mário Alexandre Coelho Sinhoreti
Host: Jean-François Roulet
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Research place: University of Florida, Gainesville (UF), United States  


The aim of this study is to evaluate the re-mineralization potential of an experimental multi-mode adhesive system containing biomimetic analogs and bioactive calcium phosphates. The experimental multi-mode adhesive system will consist in a primer (15 wt % GDMA-P; 10 wt % HEMA, 15 wt % TEG-DMA, 10 wt % UDMA, 10 wt % water and 40 wt % ethanol); and an hydrophobic bond (40 wt % UDMA, 37 wt % BisEMA, 10 wt % TEGDMA, 10 wt % GDMA-P and 3 wt % photo-initiator system). The bio-mimetic analogs (5 wt % polyacrylic acid and 10 wt % polyvinylphosphonic acid) and the bioactive phosphates (ß tricalcium phosphate and the monocalcium phosphate monohydrate) will be tested in the primer and hydrophobic bond, respectively, in which, the bioactive phosphates will consist in 20 wt % of the final blend. 46 teeth will be used to analyze the re-mineralization potential of the experimental multi-mode adhesive system by ATR/FT-IR, nanomechanical properties and TEM using the Gandolfi's technique, in which, experimental multi-mode adhesive discs will be placed on both sides of collagen discs and held together with rubber bands. 60 human third molars will be used to evaluate the microtensile bond strength (µTBS) in an OM100 machine, using a testing jig (Geraldeli's) and nanoleakage using the silver nitrate method in SEM. To assess the degree of conversion, a ATR/FT-IR will be used to measure the non-polymerized and post-polymerized blends. Data will be submitted to proper statistical analyses according to each test. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MÁRIO ALEXANDRE COELHO SINHORETI; EVELINE FREITAS SOARES; GABRIEL FLORES ABUNA; LOURENÇO CORRER SOBRINHO; JEAN-FRANÇOIS ROULET; SAULO GERALDELI. Microtensile Bond Strength of Adhesive Systems in Different Dentin Regions on a Class II Cavity Configuration. Brazilian Dental Journal, v. 28, n. 4, p. 474-481, . (14/11301-4)

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