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Effect of treatment with pentoxifylline on testicular and sperm parameters in stallions with testicular degeneration

Grant number: 14/00535-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2014
Effective date (End): September 30, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Reproduction
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Frederico Ozanam Papa
Grantee:Yamê Fabres Robaina Sancler da Silva
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):16/03442-2 - Expression of estrogen and androgen receptors in the testicle of stallions with testicular degeneration treated with pentoxifylline, BE.EP.DR


The testicular degeneration is the main cause of reduced fertility in the stallion and generates significant economic impact on the equine industry. Affected animals have reduced sperm concentration and motility as well as higher percentage of morphologically abnormal sperm, reflecting on reduced fertility. Pentoxifylline has been intensively studied and used in men with poor semen quality and testicular abnormalities such as varicocele. These researches have revealed a significant increase in sperm quality and fertility of these patients. Nevertheless, pentoxifylline in horses has not been studied in patients with testicular degeneration. Therefore this study aims to evaluate the effect of oral treatment with pentoxifylline in stallions induced to testicular degeneration at about following parameters: serum hormone profile, evaluation of kinetics, morphology and sperm viability and hemodynamic (Doppler ultrasound), thermographic, histopathological and molecular testicles evaluations. Thus, the study aims assessing therapy that promises to accelerate regeneration in stallions with testicular degeneration. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Yamê Fabres Robaina Sancler da. Effect of pentoxifylline in the testicular function and sperm production of equine submitted to scrotal heat stress. 2017. Doctoral Thesis - Universidade Estadual Paulista (Unesp).

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