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Effects of aerobic physical training in obese asthmatic mice

Grant number: 14/12755-9
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2014
Effective date (End): October 31, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Rodolfo de Paula Vieira
Grantee:Jefferson Comin Jonco Aquino Junior
Home Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
Associated research grant:12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals, AP.JP

Abstract

Asthma is a chronic airways inflammatory disease, characterized mainly by the presence of eosinophils, Th2 lymphocytes, mastocytes and dendritic cells. The airways of asthmatics also present remodeling and hyperresponsiveness. In the last years, a growing number of studies have shown that the prevalence of asthma between the obese population is significantly higher compared with non-obese population. The physical training, particularly the aerobic physical training, present anti-inflammatory effects to the airways of the asthmatics as well as reduces systemic inflammation in obese subjetcs. Therefore, the present study aims to evaluate, using experimental model of asthma in obese mice, the effects of aerobic physical training on airways inflammation, remodeling and hyperresponsiveness. To this 96 male C57Bl/6 obese mice, weighing between 18-22 grams, will be distributed in the following groups (n = 8/group): Control obese (CO), Exercise obese (EO), Asthma obese (AO), Exercise asthma obese (EAO). The animals will be initially submitted to high caloric and high fat diet (55% satured fat, 29% carbohidrates and 16% proteins) during 10 weeks, followed by the induction of asthma by using house dust mite (Dermatophagoides pteronyssinus - HDM), which will composed by the administration of 100ug of HDM per mouse through intra-tracheal via, once a week, during 8 weeks. The aerobic physical training will be performed in a treadmill (60% of maximal intensity, 25% of incline, 1h/session, 5x/week, 4 weeks), begining after the third HDM administration, during 4 weeks. The parameters to be evaluated will be the physical capacity, the bronchial hyperresponsiveness, the celularity in the bronchoalveolar lavage, the number of eosinophils, lymphocytes, macrophages and neutrophils in the airways wall, the airways remodeling, the levels of cytokines (Th1, Th2, Th17) and the levels of adipokines (leptin, adiponectin and resistin) in the bronchoalveolar lavage and in the serum. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GARCIA, MONIQUE; SANTOS-DIAS, ALANA; LACERDA BACHI, ANDRE LUIS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ANDRADE-SOUZA, ADILSON SANTOS; FERREIRA, SERGIO CESAR; JONCO AQUINO-JUNIOR, JEFFERSON COMIN; ALMEIDA, FRANCINE MARIA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; LIGEIRO OLIVEIRA, ANA PAULA; et al. Creatine supplementation impairs airway inflammation in an experimental model of asthma involving P2 x 7 receptor. European Journal of Immunology, v. 49, n. 6, p. 928-939, . (12/15165-2, 12/16498-5, 14/12755-9, 14/14604-8)
ALMEIDA-OLIVEIRA, A. R.; AQUINO, JR., J. C. J.; ABBASI, A.; SANTOS-DIAS, A.; OLIVEIRA, JR., M. C.; ALBERCA-CUSTODIO, R. W.; RIGONATO-OLIVEIRA, N. C.; SALLEY-DIAS, L. P.; DAMACENO-RODRIGUES, N. R.; CALDINI, E. G.; et al. Effects of Aerobic Exercise on Molecular Aspects of Asthma: Involvement of SOCS-JAK-STAT. EXERCISE IMMUNOLOGY REVIEW, v. 25, p. 98-110, . (12/15165-2, 14/12755-9, 12/21519-1, 14/07500-1, 12/16498-5)
DAVINO-CHIOVATTO, JAIME EDUARDO; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; MACKENZIE, BREANNE; SANTOS-DIAS, ALANA; ALMEIDA-OLIVEIRA, ANA ROBERTA; JONCO AQUINO-JUNIOR, JEFFERSON COMIN; BRITO, AURILEIA APARECIDA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; DAMACENO-RODRIGUES, NILSA REGINA; LIGEIRO OLIVEIRA, ANA PAULA; et al. Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung Inflammation and Human Neutrophil Activation. ARCHIVOS DE BRONCONEUMOLOGIA, v. 55, n. 11, p. 573-580, . (12/15165-2, 14/12755-9, 14/14604-8, 14/23196-0, 14/07500-1)

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