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Synthesis of nitrones with pharmacological potential

Grant number: 14/15534-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2014
Effective date (End): August 31, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Artur Franz Keppler
Grantee:Giovanna Biazolla
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated research grant:12/07717-5 - Nitrones and hydroxylamines with pharmacological properties: synthesis, exploration of antioxidant activity and cellular studies, AP.JP


It is intended in this project synthesize unprecedented molecules containing the nitrone functional group, a group that has a great ability to trap radical species. After the synthetic step, the molecules will be subjected to in vitro tests for determine their antioxidant activity. As the effect of physiological and pharmacological compounds containing nitrones is not yet fully established, the molecules proposed in this project will be compared with nitrones and antioxidants of reference in order to understand its structure/ antioxidant activity.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MATIAS, A. C.; BIAZOLLA, G.; CERCHIARO, G.; KEPPLER, A. F.. alpha-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus. Bioorganic & Medicinal Chemistry, v. 24, n. 2, p. 232-239, . (14/15534-3, 12/07717-5, 12/01397-9)

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Filed patent(s) as a result of this research project

USO DA ALFA-ARIL, N-ARIL NITRONAS PARA O TRATAMENTO E/OU PREVENÇÃO DE DOENÇAS DESENCADEDAS PELO ESTRESSE OXIDATIVO BR1020150289430 - Universidade Federal do ABC (UFABC) . Artur Franz Keppler; Giselle Cerchiaro; Giovanna Biazolla - November 2015, 18