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Spatial analysis of pemphigus vulgaris and pemphigus foliaceus distribution within the scope of three watersheds located in the Northeast region of São Paulo State and its relation with environmental factors

Grant number: 14/10038-8
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2014
Effective date (End): August 31, 2016
Field of knowledge:Health Sciences - Nursing - Public Health Nursing
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Susana Segura Muñoz
Grantee:Beatriz Smidt Celere
Home Institution: Escola de Enfermagem de Ribeirão Preto (EERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:10/51729-2 - Relation between immunogenetics and environmental factors in a Brazilian epidemiological study of Pemphigus vulgaris and Pemphigus foliaceus, AP.TEM


Pemphigus is a rare group of autoimmune diseases manifested by vesicles or blisters on skin or on mucous membranes. It has a global incidence and in São Paulo State, Brazil, the Northeastern region has the biggest number of occurrences of Pemphigus Vulgaris (PV) and Pemphigus Foliaceous (PF). There is an assumption that genetic factors are not enough to cause the disease outbreak, thus environmental factors have been relating to the distribution of cases. It studies some environmental hypotheses in this relation, such as the contact with pesticides or the proximity to the rivers. Considering the potential environmental relations with water resources, this work will be carried out within the scope of three watersheds located in the Northeast region of São Paulo State. It aims to analyse the spatial distribution of patients with PV or PF by using georeference as a tool for generating thematic maps and for identifying potential environmental relations. MapInfo 10.0 and ArcGIS 10.2 software will position the geographic coordinates of patients with PV or PF, which allows both a spatial analysis as a digitizing of land-use surrounding the residence of each patient, in order to relate it to potential environmental factors. Given the importance of this dermatosis, the study is unpublished and crucial to guide intersectoral actions and to generate subsidies for decision making in health sector. This project complements Subproject 6 Prevalence of exposure to pesticides and heavy metals in patients samples with PV and PF, family and neighborhood, and its relationship with the Guarani aquifer and the Pardo and Mogi Guaçu rivers, which in turn is part of the thematic project Relation of the immunogenetics and environmental factors in etiopathogenesis of pemphigus in a Brazilian sampling supported by the São Paulo Research Foundation - FAPESP, Brazil (Grant 2010/51729-2). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CELERE, BEATRIZ S.; VERNAL, SEBASTIAN; BROCHADO, MARIA JOSE F.; SEGURA-MUNOZ, SUSANA I.; ROSELINO, ANA MARIA. Geographical foci and epidemiological changes of pemphigus vulgaris in four decades in Southeastern Brazil. INTERNATIONAL JOURNAL OF DERMATOLOGY, v. 56, n. 12, p. 1494-1496, . (10/51729-2, 14/10038-8)
CELERE, BEATRIZ SMIDT; VERNAL, SEBASTIAN; LA SERRA, LEONARDO; FRANCO BROCHADO, MARIA JOSE; MOSCHINI, LUIZ EDUARDO; ROSELINO, ANA MARIA; SEGURA-MUNOZ, SUSANA INES. Spatial Distribution of Pemphigus Occurrence over Five Decades in Southeastern Brazil. American Journal of Tropical Medicine and Hygiene, v. 97, n. 6, p. 1737-1745, . (14/10038-8, 10/51729-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CELERE, Beatriz Smidt. Analysis of the spatial distribution of pemphigus vulgaris and pemphigus foliaceus under three watersheds present in the northeastern state of São Paulo and the relationship with environmental factors. 2016. Master's Dissertation - Universidade de São Paulo (USP). Escola de Enfermagem de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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