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The role of SOCS3 in the control of hyperphagia, body weight regain and gluconeogenesis after a period of food restriction

Grant number: 13/25032-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2014
Effective date (End): November 30, 2016
Field of knowledge:Biological Sciences - Physiology - General Physiology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Jose Donato Junior
Grantee:João Alfredo Bolivar Pedroso
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:10/18086-0 - Molecular basis of leptin resistance, AP.JP


Studies have shown that most individuals trying to lose weight regains the lost weight along time. This fact impairs the treatment of obesity in the long term. Additionally, although the hormone leptin plays a key role in the control of food intake and energy balance, most obese individuals has high circulating levels of this hormone. Therefore, it is believed that obesity is characterized by a leptin resistance state. In this context, several studies have shown that a group of proteins known as suppressors of cytokine signal (SOCS) has a substantial role in the etiology of leptin resistance, because they act as signaling inhibitors of this hormone. Although it is quite clear the involvement of SOCS3 on leptin resistance caused by diet-induced obesity, no study has investigated the involvement of this protein in the hyperphagia and the body weight regain after a period of caloric restriction. Thus, the aim of this study is to investigate the role of SOCS3 as a molecular component that amplifies the hyperphagia after a period of food restriction. Therefore, mice with inactivation of Socs3 gene only in leptin receptor-expressing cells were used. These animals will be subjected to a protocol of food restriction and their food intake and weight regain will be followed during the refeeding period. Biochemical and molecular biological analyzes will be used to elucidate the role of SOCS3 in the hyperphagia observed after the period of food restriction. In addition, preliminary results indicate an important role of SOCS3 in the control of gluconeogenesis during fasting conditions which will be investigated in detail in this project. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEDROSO, JOAO A. B.; RAMOS-LOBO, ANGELA M.; DONATO, JR., JOSE. SOCS3 as a future target to treat metabolic disorders. HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, v. 18, n. 2, p. 127-136, . (13/25032-2, 14/11752-6, 17/02983-2)
PEDROSO, JOAO A. B.; SILVEIRA, MARINA A.; LIMA, LEANDRO B.; FURIGO, ISADORA C.; ZAMPIERI, THAIS T.; RAMOS-LOBO, ANGELA M.; BUONFIGLIO, DANIELLA C.; TEIXEIRA, PRYSCILA D. S.; FRAZAO, RENATA; DONATO, JR., JOSE. Changes in Leptin Signaling by SOCS3 Modulate Fasting-Induced Hyperphagia and Weight Regain in Mice. Endocrinology, v. 157, n. 10, p. 3901-3914, . (13/25032-2, 10/18086-0, 14/11752-6, 12/12202-4, 15/10992-6, 13/07908-8, 12/15517-6, 13/21722-4)
PEDROSO, JOAO A. B.; DA SILVA, IVSON B.; ZAMPIERI, THAIS T.; TOTOLA, LEONARDO T.; MOREIRA, THIAGO S.; TANIGUTI, ANA P. T.; DINIZ, GABRIELA P.; BARRETO-CHAVES, MARIA LUIZA M.; DONATO, JOSE, JR.. SOCS3 Ablation in Leptin Receptor-Expressing Cells Causes Autonomic and Cardiac Dysfunctions in Middle-Aged Mice despite Improving Energy and Glucose Metabolism. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 12, p. 19-pg., . (12/15517-6, 11/12893-4, 10/18086-0, 13/04703-6, 13/25032-2)
FURIGO, ISADORA C.; SUZUKI, MIRIAM F.; OLIVEIRA, JOAO E.; RAMOS-LOBO, ANGELA M.; TEIXEIRA, PRYSCILA D. S.; PEDROSO, JOAO A.; DE ALENCAR, AMANDA; ZAMPIERI, THAIS T.; BUONFIGLIO, DANIELLA C.; QUARESMA, PAULA G. F.; et al. Suppression of Prolactin Secretion Partially Explains the Antidiabetic Effect of Bromocriptine in ob/ob Mice. Endocrinology, v. 160, n. 1, p. 193-204, . (13/25032-2, 14/11752-6, 15/10992-6, 12/15517-6, 13/21722-4, 17/25281-3, 12/24345-4)
PEDROSO, JOAO A. B.; ZAMPIERI, THAIS T.; DONATO, JR., JOSE. Reviewing the Effects of l-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis. NUTRIENTS, v. 7, n. 5, p. 3914-3937, . (13/25032-2, 12/15517-6, 10/18086-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PEDROSO, João Alfredo Bolivar. The effect of SOCS3 deletion from leptin responsive cells in different experimental conditions.. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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