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In vivo study of the effects of the endocrine disruptor glyphosate in the hypothalamic-pituitary-thyroid axis

Grant number: 14/06834-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2014
Effective date (End): July 31, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Maria Izabel Chiamolera
Grantee:Gabriel Glebocki
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Endocrine Disruptors (ED) can be defined as exogenous compounds with the potential to alter standard hormone regulation and endocrine system. Such interference may occur in the production, release, metabolism and elimination of hormones. Furthermore, these substances can mimic natural hormone actions, causing changes in normal physiological functions. In this project we opted to study one of the major currently used ED that might affect men's health: glyphosate based herbicides, which are widely used, especially in transgenic plantations. Preliminary data shown that prenatal exposure of rats with a compound containing glyphosate resulted in a decrease of the mRNA content of TSH beta subunit, however, with increased protein content. Other than that little is known about how glyphosate can influence the regulation of the HPT axis. Therefore, we aim at studying the influence of perinatal exposure to glyphosate in rats HHT axis. To reach that goal hormonal and gene expression profiles will be evaluated in order to estimate HHT axis function. Therefore, the results of this project could provide better understand in the mechanisms of action of this ED and help assess the possible impact of these on public health.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, JANAINA SENA; LETRO KIZYS, MARINA MALTA; DA CONCEICAO, RODRIGO RODRIGUES; GLEBOCKI, GABRIEL; ROMANO, RENATA MARINO; ORTIGA-CARVALHO, TANIA MARIA; GIANNOCCO, GISELE; COTRIM GUERREIRO DA SILVA, ISMAEL DALE; DIAS DA SILVA, MAGNUS REGIOS; ROMANO, MARCO AURELIO; et al. Perinatal exposure to glyphosate-based herbicide alters the thyrotrophic axis and causes thyroid hormone homeostasis imbalance in male rats. Toxicology, v. 377, p. 25-37, . (14/06834-3, 14/15948-2, 13/26851-7, 12/01628-0)

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