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Identification of signature of selection in three Nellore cattle lineages selected for growth

Grant number: 14/13445-3
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): September 10, 2014
Effective date (End): September 09, 2015
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal researcher:Humberto Tonhati
Grantee:Diercles Francisco Cardoso
Supervisor abroad: Henner Simianer
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Research place: Göttingen University, Germany  
Associated to the scholarship:12/24600-4 - Identification of signature selection in three lineages of Nellore cattle selected for growth, BP.DR


Identified genomic regions under influence of selection are termed as selection signatures. The changes of the genetic constitution might be associated with be proximity of these regions with a potential QTL for the trait selected. So, this study has the aim to find selection signatures in Nellore cattle from comparisons methods. It will be use data of 771 animals belonging to experimental population raised in the Instituto de Zootecnia - Centro APTA Bovinos de Corte (IZ), which is divided in herds selected and no selected to yearling body weight. The method used for signatures identification will be the comparison of Extended Haplotype Homozygosity between populations. The regions will be considered signature only in selected herds and related with the trait selected, while signature identified in both herds may be related to the breed standart or evolutionary history of the breed. The validating of selection signatures will be performed as following: i) Comparison between signatures identified with two different methods; ii) Association study of the signatures more significant with phenotypic information; iii) Scanning for QTL previously described for weight near signatures. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARDOSO, DIERCLES F.; DE ALBUQUERQUE, LUCIA GALVAO; REIMER, CHRISTIAN; QANBARI, SABER; ERBE, MALENA; DO NASCIMENTO, ANDRE V.; VENTURINI, GUILHERME C.; BECKER SCALEZ, DAIANE C.; BALDI, FERNANDO; FERREIRA DE CAMARGO, GREGORIO M.; et al. Genome-wide scan reveals population stratification and footprints of recent selection in Nelore cattle. GENETICS SELECTION EVOLUTION, v. 50, . (09/16118-5, 12/24600-4, 14/13445-3)

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