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Role endogenous of hydrogen sulphide (H2S) in the NTS on respiratory activity during hypoxia

Grant number: 14/12951-2
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): November 01, 2014
Effective date (End): October 31, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Luiz Guilherme de Siqueira Branco
Grantee:João Paulo Jacob Sabino
Supervisor: Gregory Douglas Funk
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: University of Alberta, Canada  
Associated to the scholarship:11/14779-4 - Effect of hydrogen sulfide (H2S) in the commissural NTS on the ventilatory and hemodynamic response to hypoxia and hypercapnia in normotensive and hypertensive animals, BP.PD


Hydrogen sulfide (H2S) has recently been considered an additional endogenous gasotransmitter and within the central nervous system, H2S is predominantly produced by the enzyme cystathionine-²-synthase (CBS). CBS-produced H2S may regulate the cardiorespiratory system and modulates peripheral chemoreceptor sensory afferents that project to the nucleus tractus solitarus (NTS), as well as the ventilatory response to a brief hypoxic challenge. The H2S augments synaptic transmission between visceral afferents and second-order neurons via mechanisms at the presynaptic terminal, including enhancement in intracellular calcium, rather than altering postsynaptic properties. However, no information exists in regards to the effect of endogenous H2S in NTS on respiratory control in rats. Therefore, in the present study we will evaluate the effects of central microinjections (NTS) of H2S donor [sodium sulphide (Na2S)] and inhibitor (AOAA) on respiratory muscle activity. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, GLAUBER S. F.; SABINO, JOAO P. J.; RAJANI, VISHAAL; ALVARES, TUCAAUE S.; PAGLIARDINI, SILVIA; BRANCO, LUIZ G. S.; FUNK, GREGORY D.. Excitatory Modulation of the preBotzinger Complex Inspiratory Rhythm Generating Network by Endogenous Hydrogen Sulfide. FRONTIERS IN PHYSIOLOGY, v. 8, . (14/12951-2, 13/17606-9, 12/02413-8)

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