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Participation of intracellular pathways modulated by carbon monoxide in the regulation of hydroeletrolitic balance

Grant number: 14/10060-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2014
Effective date (End): November 01, 2018
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:José Antunes Rodrigues
Grantee:Juliana Bezerra Medeiros de Lima
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/09799-1 - Energy balance and body fluid homeostasis control: from cells to the physiological systems, AP.TEM
Associated scholarship(s):17/13653-3 - Dehydration-induced carbon monoxide generation: participation of ROS, redox signaling and the Nrf2-are pathway, BE.EP.DR


Hydroelectrolytic balance that is essential to life mainteinance has an efficient and complex control, which is performed moment to moment by several homeostatic systems. In this context, neuroendocrine system acts as command and integration compound of effector responses in face of any situation that challenges hydric and electrolytic homeostasis. Recently, evidences of gaseous modulators participation have been reported, including carbon monoxide (CO), in regulation of this and other homeostatic systems. Previous data from literature and unpublished studies from our group indicate that CO can modulate hormone secretion in many experimental conditions, such as extracellular volume expansion and water deprivation, either directly or indirectly - by nitric oxide (NO) system modulation - and this modulation can happen time- or stimulus-dependently. Thus, the present study aims to evaluate the modulation by central CO on 24-h and 48-h water deprivation-induced neuroendocrine responses, investigating 1) possible CO intracellular targets - soluble guanylate cyclase (sGC), large conductance potassium channels (BK) and mitogen-activated protein kinase 38 (p38 MAPK); 2) possible interaction of NO and CO systems and 3) probable existence of a time-dependent factor on modulation of these responses. In order to achieve these aims, electrophysiological as well as radioimmunoassay, western blotting and immunohistochemistry studies will be performed. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LIMA, Juliana Bezerra Medeiros de. Participation of intracellular pathways modulated by carbon monoxide in the regulation of hydroeletrolitic balance. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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