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Vaccination with activated dendritic cells in the prophylaxis of experimental sporotrichosis in immunosuppressed mice

Grant number: 14/00914-5
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2014
Effective date (End): July 31, 2017
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Iracilda Zeppone Carlos
Grantee:Camila Cristina Quinello Gomes de Faria
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Sporotrichosis is an important mycosis with worldwide distribution that affects humans and animals. The fungal infection is usually caused by traumatic inoculation of fungus Sporothrix schenckii ( S. schenckii) and clinical manifestations may differ from skin infection, lymphocutaneous and systemic infection, most commonly seen in immunocompromised patients. Cases of sporotrichosis caused by cat scratching and contact with its contaminated wounds were reported in several cities in Brazil and in the city of Rio de Janeiro the disease assumed epidemic proportions. Studies have been shown that the use of dendritic cells as a tool for developing vaccines to various fungi. However, studies related to this methodology to fungal infections, especially in sporotrichosis, are still rare and there´s a great need from the cientific community to clarify the important role of dendritic cell vaccine for prophylactic and / or therapeutic. Therefore, the study´s aim is to evaluate the protective ability of activated-dendritic cells isogenic in model of infection by S. schenckii, mimetizing the natural route of infection by subcutaneous in animals with induced immunosuppression. The use of dendritic cells stimulated with S. schenckii inoculated subcutaneously may in the future serve as a study source to generate therapeutic and vaccine tools in sporotrichosis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MANENTE, FRANCINE ALESSANDRA; QUINELLO, CAMILA; FERREIRA, LUCAS SOUZA; DE ANDRADE, CLEVERTON ROBERTO; JELLMAYER, JULIANA APARECIDA; PORTUONDO, DEIVYS LEANDRO; BATISTA-DUHARTE, ALEXANDER; CARLOS, IRACILDA ZEPPONE. Experimental sporotrichosis in a cyclophosphamide-induced immunosuppressed mice model. Medical Mycology, v. 56, n. 6, p. 711-722, . (15/04023-0, 14/00914-5)
QUINELLO, CAMILA; FERREIRA, LUCAS SOUZA; PICOLLI, ISABELLA; LOESCH, MARIA LUIZA; PORTUONDO, DEIVYS LEANDRO; BATISTA-DUHARTE, ALEXANDER; CARLOS, IRACILDA ZEPPONE. Sporothrix schenckii CellWall Proteins-Stimulated BMDCs Are Able to Induce a Th1-Prone Cytokine Profile In Vitro. JOURNAL OF FUNGI, v. 4, n. 3, . (15/04023-0, 14/00914-5)

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