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Chemical and biological study of two strains of endophytic fungi isolated from guarana leaves of Amazonas

Grant number: 14/05940-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2014
Effective date (End): June 30, 2015
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Simone Possedente de Lira
Grantee:Marília Capellaro Ferreira
Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil


Endophytic fungi are involved in production of compounds of biotechnological interest as novel bioactive with applications in medicine, industry and agriculture compounds. These microorganisms are important candidates for the control of plant pathogens, including fungi of the genus Colletotrichum, which are considered one of the major phytopathogen of the world, causing significant economic damage to various crops. Guarana (Paullinia cupana var. Sorbilis (Mart.) Duke) is native from Amazon and is a major product of the states of Amazonas and Bahia. The culture of guarana is economically and socially important to Brazil. Considering the possible control of diseases through the use of bioactive compounds produced by microorganisms, this project aims to prospecting chemical and biologically compounds produced by endophytic fungi of guarana with antifungal activity to Colletotrichum sp. For the development of the project will be selected two strains of endophytic fungi with promising activity. The strains are grown in specific culture medium and produced metabolites are separated and isolated by chromatographic methods and identified by spectroscopic methods. All extracts and fractions obtained in biological assays will be evaluated against mycelial growth "in vitro" of Colletotrichum sp.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ELIAS, LUCIANA M.; FORTLZAMP, DIANA; SARTORI, SERGIO B.; FERREIRA, MARILIA C.; GOMES, LUIZ H.; AZEVEDO, JOAO L.; MONTOYA, V, QUIMI; RODRIGUES, ANDRE; FERREIRA, ANTONIO G.; LIRA, SIMONE P.. The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnose. Brazilian Journal of Microbiology, v. 49, n. 4, p. 840-847, . (14/05940-4, 14/15760-3, 12/02000-5, 13/50228-8)

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