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Effects of probiotic therapy in the periodontitis associated with diabetes mellitus: a morphometric study in rats

Grant number: 14/06876-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2014
Effective date (End): July 31, 2015
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Michel Reis Messora
Grantee:Giselle Aparecida da Silva
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Considering the antidiabetic, antibacterial and imumoduladores effects of probiotics, their use for prevention and treatment of periodontitis in diabetic patients seems to be a promising strategy. The purpose of this study is to evaluate the effects of systemic administration of the strain Bifidobacterium animalis subsp. lactis HN019 in ligature-induced periodontitis in diabetic rats. Seventy-six rats will be randomly divided into 8 groups: DM, DM/PROB, DM/PD, DM/PD/PROB, C, C/PROB, C/PD e C/PD/PROB. In groups PD, the right mandibular 1st molar of the animals will receive a cotton ligature that will be left in the same position during 14 days. In groups PROB, the strain HN019 will be administered orally to the animals for 4 weeks. In groups DM, the animals will receive an intraperitoneal injection of streptozotocin in order to induce diabetes mellitus. In groups C, the animals will be systemically healthy. All animals will be euthanized 5 weeks after the start of the study. The jaws will be resected and morphometric analysis will be performed in order to evaluate the alveolar bone loss. The data obtained will be subjected to statistical analysis.

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