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Lineage factor evaluation of aversive learning test anxiety levels in good and bad performance animals: Wistar versus Sprague Dawley

Grant number: 14/12999-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2014
Effective date (End): June 30, 2015
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal Investigator:Raquel Chacon Ruiz Martinez
Grantee:Lennon Tosati Cardoso Dos Santos
Host Institution: Hospital Sírio-Libanês. Sociedade Beneficente de Senhoras (SBSHSL). São Paulo , SP, Brazil
Associated research grant:11/08575-7 - The role of dopaminergic modulation in the lateral nucleus of amygdala during active avoidance response, AP.JP


The two-way active avoidance is an animal model of aversive learning, in which we can observe two distinct subpopulations of animals, the good and the poor performers. It has been suggested that there is a correlation between the aversive system and the anxiety levels, then the aim of this work is to elucidate whether there are previous differences between the level of fear and anxiety in these animals. For that, Male Wistar rats weighing between 250-300g will be used. The animals will be received at the Vivarium, for a 72 hours habituation period. Then the anxiety level of these animals will be evaluated using the most used anxiety model nowadays, the elevated plus maze (Pellow et al., 1985). The animals will be individually placed in the central area of the maze with the head directed toward one of the closed arms with the possibility to freely explore the equipment for 5 minutes. The experimental sessions will be monitored and recorded and it will be done the behavioral analysis to evaluate the number and time spent in the open and closed, the percentage of entries into open arms, the exploration the open ends, rearing, stretching and dipping and grooming. Next, the animals will be trained for seven days in the two-way active avoidance to determine the good and poor performers (display of less than avoidance responses for at least 2 consecutive days). It will be correlated the level of anxiety of the animals with the performance in the avoidance test.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SENO, MIDIA D. J.; ASSIS, DANIELLE V.; GOUVEIA, FLAVIA; ANTUNES, GEIZA F.; KUROKI, MAYRA; OLIVEIRA, CAROLINE C.; SANTOS, LENNON C. T.; PAGANO, ROSANA L.; MARTINEZ, RAQUEL C. R.. The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy. SCIENTIFIC REPORTS, v. 8, . (15/26079-8, 11/08575-7, 14/12999-5, 13/20602-5)
ANTUNES, GEIZA FERNANDA; GOUVEIA, FLAVIA VENETUCCI; REZENDE, FABIANA STRAMBIO; DE JESUS SENO, MIDIA DIAS; DE CARVALHO, MILENE CRISTINA; DE OLIVEIRA, CAROLINE CRUZ; TOSATI DOS SANTOS, LENNON CARDOSO; DE CASTRO, MARINA CORREIA; KUROKI, MAYRA AKEMI; TEIXEIRA, MANOEL JACOBSEN; et al. Dopamine modulates individual differences in avoidance behavior: A pharmacological, immunohistochemical, neurochemical and volumetric investigation. NEUROBIOLOGY OF STRESS, v. 12, . (17/10466-8, 13/20602-5, 11/08575-7, 14/12999-5)
DE OLIVEIRA, CAROLINE C.; GOUVEIA, FLAVIA V.; DE CASTRO, MARINA C.; KUROKI, MAYRA A.; DOS SANTOS, LENNON C. T.; FONOFF, ERICH T.; TEIXEIRA, MANOEL J.; OTOCH, JOSE P.; MARTINEZ, RAQUEL C. R.. A Window on the Study of Aversive Instrumental Learning: Strains, Performance, Neuroendocrine, and Immunologic Systems. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 10, . (11/08575-7, 14/12999-5, 13/20602-5)

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