Characterization of Cordia verbenacea DC sustained release using natural latex biomembranes as carrier

Abstract

The Natural Rubber Latex (NRL) membrane manipulated from the latex extracted from the rubber tree Hevea brasiliensis, has shown great potential for biomedical applications and as biomaterials. Due to its biocompatibility and low risk of rejection, it can stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, besides acting as a mechanical barrier to infectious agents. The aim of this study is to develop a novel sustained delivery system for Cordia verbenacea DC. based on Natural Rubber Latex (NRL) membranes and to study the Cordia Verbenacea DC. delivery system behavior. The Cordia Verbenacea DC. is an anti-inflammatory, anti-ulcer, anti-rheumatic and healing plant that has therapeutic properties and low toxicity, thanks to the action of the essential oil, which has the active ingredient alpha-humulene. The use of a controlled release system, coupled with the angiogenic properties of latex, seeking to extract-biomembrane interaction, and thus ensure the improvement of the effects of the herbal medicine, as well as offering a cheaper and affordable alternative to those existing in market. The release rates of extract the complex drug-extract-film will be monitored and analyzed, using the method of optical spectroscopy (UV-VIS), and will be characterized by Scanning Electron Microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and mechanical resistance tests.