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Gene expression profiling in hepatic tissue of Nelore steers with divergent profiles for residual feed intake

Grant number: 14/13555-3
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): September 07, 2014
Effective date (End): March 06, 2015
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal researcher:Luciana Correia de Almeida Regitano
Grantee:Polyana Cristine Tizioto
Supervisor abroad: Jeremy Francis Taylor
Home Institution: Embrapa Pecuária Sudeste. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
Research place: University of Missouri, Columbia (UM), United States  
Associated to the scholarship:13/17778-4 - Tanscriptomic profile of extreme animals for feed efficiency of Nelore breed, BP.PD


Feed efficiency is an extremely important production trait, however, despite its known moderate heritability, this trait has not being considered in genetic evaluation programs, because measurement is costly and occurs late in animal's life. Selection for more efficient animals may contribute to reductions in pasture area and pollutant production (methane and manure), despite allowing for increases in profitability of producers. Recent developments in molecular genetics, such as platforms for genotyping and genome sequencing, provide an opportunity to identify genes and pathways related to production traits such as feed efficiency. This study attempts to identify differentially expressed genes in animals genetically divergent for Residual Feed Intake (RFI), using RNA sequencing (RNAseq) to obtain information from genome wide expression profiles in muscle and liver tissues. This study will provide insights into the molecular mechanisms which underlie RFI. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TIZIOTO, POLYANA C.; COUTINHO, LUIZ L.; DECKER, JARED E.; SCHNABEL, ROBERT D.; ROSA, KAMILA O.; OLIVEIRA, PRISCILA S. N.; SOUZA, MARCELA M.; MOURAO, GERSON B.; TULLIO, RYMER R.; CHAVES, AMALIA S.; et al. Global liver gene expression differences in Nelore steers with divergent residual feed intake phenotypes. BMC Genomics, v. 16, . (13/17778-4, 14/13555-3)
TIZIOTO, POLYANA C.; COUTINHO, LUIZ L.; OLIVEIRA, PRISCILA S. N.; CESAR, ALINE S. M.; DINIZ, WELLISON J. S.; LIMA, ANDRESSA O.; ROCHA, MARINA I.; DECKER, JARED E.; SCHNABEL, ROBERT D.; MOURAO, GERSON B.; et al. Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake. SCIENTIFIC REPORTS, v. 6, . (12/23638-8, 13/17778-4, 14/13555-3)

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