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Influence of high fat diets on lipid energy metabolism and cardiac dysfunction in rodents during chronic cardiac stress

Grant number: 14/06030-1
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): October 01, 2014
Effective date (End): September 30, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Antonio Carlos Cicogna
Grantee:Loreta Casquel de Tomasi
Supervisor abroad: Stephen C. Kolwicz
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Research place: University of Washington, United States  
Associated to the scholarship:12/19679-0 - Influence of unsaturated high-fat diet in the lipid energy metabolism regulation and in the cardiac dysfunction in rats with supravalvar aortic stenosis, BP.DR


This project aims to study: 1) the effects of hyperlipidic dietary treatment on energy metabolism and cardiac function after the establishment of ventricular hypertrophy accompanied by diastolic dysfunction in rats with supravalvar aortic stenosis; and 2) to investigate whether enhanced endogenous lipid metabolism exerts a cardioprotective effect during chronic lipid overload, by reducing availability of the toxic lipid intermediates, ceramides and diacylglycerol in transgenic mouse overexpressing cardiac specific diacylglycerol acyltransferase 1. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE TOMASI, LORETA CASQUEL; SALOME CAMPOS, DIJON HENRIQUE; SANT'ANA, PAULA GRIPPA; OKOSHI, KATASHI; PADOVANI, CARLOS ROBERTO; MURATA, GILSON MASAHIRO; NGUYEN, SON; KOLWICZ, JR., STEPHEN C.; CICOGNA, ANTONIO CARLOS. Pathological hypertrophy and cardiac dysfunction are linked to aberrant endogenous unsaturated fatty acid metabolism. PLoS One, v. 13, n. 3, . (12/19679-0, 14/06030-1)

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