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Intra-host genetic diversity of Dengue virus type 4 strains from the municipality of Guarujá, São Paulo

Grant number: 13/25434-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): July 01, 2014
Effective date (End): June 30, 2016
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Paolo Marinho de Andrade Zanotto
Grantee:Ayda Susana Ortiz Baez
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Characterizing intra-host genetic variability in dengue virus (DENV) virus is paramount for understanding its evolution and population dynamics in the context of its current status as a major human pathogen. The extent to which viral diversity accrues in infected hosts influences aspects such as pathogenesis, transmission, and host immunity. Although there are several studies about intra-host genetic diversity in dengue, limited amount of data has been reported for DENV-4 so far. In the Guarujá Municipality in the State of São Paulo, the reemergence and spread of this serotype was associated with its co-circulation and the displacement of serotypes 1, 2 and 3 during recent outbreaks (Villabona-Arenas et al., PLoS NTD in Press). Based on this epidemiological framework, we seek to identify the intra-host genetic variation of DENV-4 strains from samples collected during the 2013 outbreak by using deep sequencing technologies. We will estimate the level of variability and the evolutionary history of these viruses in response to selective pressures imposed by an urban population previously exposed to the remaining three dengue serotypes. This study would also be the first effort to investigate the intra-host diversity of DENV-4. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CUNHA, MARIELTON DOS PASSOS; DUARTE-NETO, AMARO NUNES; POUR, SHAHAB ZAKI; ORTIZ-BAEZ, AYDA SUSANA; CERNY, JIRI; DE SOUZA PEREIRA, BARBARA BRITO; BRACONI, CARLA TORRES; HO, YEH-LI; PERONDI, BEATRIZ; SZTAJNBOK, JAQUES; et al. Origin of the Sao Paulo Yellow Fever epidemic of 2017-2018 revealed through molecular epidemiological analysis of fatal cases. SCIENTIFIC REPORTS, v. 9, . (17/23281-6, 13/25434-3, 13/21728-2, 16/08204-2)
ORTIZ-BAEZ, AYDA SUSANA; CUNHA, MARIELTON DOS PASSOS; VEDOVELLO, DANILA; COLOMBO, TATIANA ELIAS; NOGUEIRA, MAURICIO LACERDA; VILLABONA-ARENAS, CHRISTIAN JULIAN; DE ANDRADE ZANOTTO, PAOLO MARINHO. Origin, tempo, and mode of the spread of DENV-4 Genotype IIB across the state of São Paulo, Brazil during the 2012-2013 outbreak. Memórias do Instituto Oswaldo Cruz, v. 114, . (13/25434-3, 16/08204-2, 11/17071-2)
CUNHA, MARIELTON DOS PASSOS; ORTIZ-BAEZ, AYDA SUSANA; DE MELO FREIRE, CAIO CESAR; DE ANDRADE ZANOTTO, PAOLO MARINHO. Codon adaptation biases among sylvatic and urban genotypes of Dengue virus type 2. INFECTION GENETICS AND EVOLUTION, v. 64, p. 207-211, . (13/25434-3, 16/08204-2)
ORTIZ-BAEZ, AYDA SUSANA; SILVA, DANIELLE FERREIRA; FERREIRA, DANIEL; ZANOTTO, PAOLO M.. First Genome Sequences of Dengue Virus (DENV) Strains Isolated during the First DENV-4 Outbreak in Sao Paulo, Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 5, n. 28, . (13/25434-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BAEZ, Ayda Susana Ortiz. Intra-host genetic diversity of dengue virus type 4 strains from the municipality of Guarujá,. 2016. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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