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Speciation of selenium and their relation with the time of exposure to antiretroviral therapy in HIV-infected patients

Grant number: 13/25228-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): July 01, 2014
Effective date (End): October 31, 2015
Field of knowledge:Health Sciences - Nutrition
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Anderson Marliere Navarro
Grantee:Lígia Moriguchi Watanabe
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):14/22628-4 - Effects of alterations in selenium recycling, BE.EP.MS


Introduction: Among the many factors that impact the progress of a disease are feeding and nutritional status. Impairment of macro and micronutrients may have an impact on immunity that modifies the course of chronic/infection long-term disease. In the pathogenesis of AIDS, a selenium deficient state may contribute to the progress of HIV infection, and as the beneficial effects of selenium are dependent on its chemical form and concentration, the importance of selenometabolomic stands out. Objective: To evaluate the effect of selenium and total metabolites in HIV-infected patients according to the time of exposure to antiretroviral. Methodology: This is a cross-sectional study to be conducted at the Hospital das Clínicas de Ribeirão Preto da Faculdade de Medicina de Ribeirão Preto. Participants (n=120) will be grouped according to the time of exposure to antiretroviral therapy (HAART) in: control group seronegative for HIV: n=40; group> 5 years of treatment with HAART: n=40 and group <5 year treatment with HAART: n=40. Total erythrocyte and serum selenium will be evaluated, besides serum selenium metabolites by HPLC-ICPMS technique. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
WATANABE, LIGIA MORIGUCHI; BARBOSA JUNIOR, FERNANDO; JORDAO, ALCEU AFONSO; NAVARRO, ANDERSON MARLIERE. Influence of HIV infection and the use of antiretroviral therapy on selenium and selenomethionine concentrations and antioxidant protection. NUTRITION, v. 32, n. 11-12, p. 1238-1242, . (13/25228-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
WATANABE, Lígia Moriguchi. Influência da infecção pelo HIV e do uso da terapia antirretroviral nas concentrações de selênio, selenometionina e proteção antioxidante. 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.

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