Advanced search
Start date

Remote loading of dibucaine into liposomes using transmembranar ionic gradient

Grant number: 13/13965-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): July 01, 2014
Effective date (End): February 28, 2015
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Eneida de Paula
Grantee:Verônica Muniz Couto
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Dibucaine is a Local Anesthetic (LA) of amino-amides class which has potential use as topical anesthetics. Currently, it is indicated for rectal inflammation, such as hemorrhoids. This LA is being studied in Biomembranes research group (IB-UNICAMP) about it interaction with phospholipid membranes, formulation development with nanostructured lipid carriers and cyclodextrins, with very promising results. In this study, we encapsulate the dibucaine in liposomes prepared with ionic gradient and test in vitro and in vivo. Its effectiveness will be compared to commercial formulations of dibucaine currently available in the pharmaceutical market. Therefore, we propose to continue our line of research: drug delivery for local anesthetics, developing and characterizing a pharmaceutical formulation for dibucaine in liposomes with transmembrane gradient internal-external ion. Through a simple and fast process of encapsulation, the aim is to increase the time of sensory block and reduce local and systemic toxicity of dibucaine for future clinical application of topical and/or infiltrative process in the treatment of pain. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COUTO, VERONICA M.; PRIETO, MARIA J.; IGARTUA, DANIELA E.; FEAS, DANIELA A.; RIBEIRO, LIGIA N. M.; SILVA, CAMILA M. G.; CASTRO, SIMONE R.; GUILHERME, VIVIANE A.; DANTZGER, DARLENE D.; MACHADO, DAISY; et al. Dibucaine in Ionic-Gradient Liposomes: Biophysical, Toxicological, and Activity Characterization. Journal of Pharmaceutical Sciences, v. 107, n. 9, p. 2411-2419, . (13/13965-4, 14/14457-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
COUTO, Verônica Muniz. Remote loading of dibucaine into liposomes using transmembranar ionic gradient. 2015. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

Please report errors in scientific publications list using this form.