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Modulation of the S6Ks expression in the central nervous system and their effect in obesity

Grant number: 13/22696-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2014
Effective date (End): February 29, 2016
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Fernando Moreira Simabuco
Grantee:Mariana Rosolen Tavares
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated research grant:12/13558-7 - Molecular characterization of S6Ks in obesity and its associated diseases, AP.JP


Obesity has been considered a worldwide epidemic. In Brazil, more than half of the population is overweight and obesity values continue to rise. World Health Organization (WHO) data are categorical to assert that obesity is related to a number of diseases, including: Diabetes Mellitus type II, cardiovascular disease, Cerebrovascular Accident (CVA), dyslipidemia, osteoarthritis and some types of cancer. Thus, there is currently great demand for a better understanding of the biochemical and metabolic processes related to obesity. The signaling pathway of mTOR protein has been associated with the control of energy balance in the body, working as a sensor of the amount of nutrients available and signaling to the expenditure of the stored energy. The present research project aims to study the role of S6Ks, known effectors of mTOR, in the Central Nervous System (CNS) and its consequences for energy homeostasis. For that, protein expression of the different S6Ks isoforms will be modulated in the CNS to characterize their roles in CNS, as well as their peripheral effects in the body. It is clear the demand to fully investigate the pathway of mTOR/S6Ks due to its importance in metabolic changes, obesity and associated pathologies. Only with complete understanding of the functions of S6Ks, effectors of mTOR pathway, it will be possible to develop safe and effective treatments for those pathologies. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TAVARES, MARIANA ROSOLEN; LEMES, SIMONE FERREIRA; DE FANTE, THAIS; DE MIERA, CRISTINA SAENZ; BETIM PAVAN, ISADORA CAROLINA; NEVES BEZERRA, ROSANGELA MARIA; PRADA, PATRICIA OLIVEIRA; TORSONI, MARCIO ALBERTO; ELIAS, CAROL FUZETI; SIMABUCO, FERNANDO MOREIRA. Modulation of hypothalamic S6K1 and S6K2 alters feeding behavior and systemic glucose metabolism. Journal of Endocrinology, v. 244, n. 1, p. 71-82, . (12/13558-7, 13/22696-7, 18/14818-9, 18/07018-6, 15/24475-3, 16/06457-0)
TAVARES, MARIANA R.; PAVAN, ISADORA C. B.; AMARAL, CAMILA L.; MENEGUELLO, LETICIA; LUCHESSI, AUGUSTO D.; SIMABUCO, FERNANDO M.. The S6K protein family in health and disease. Life Sciences, v. 131, p. 1-10, . (14/01386-2, 13/22696-7, 12/13558-7)
PAVAN, ISADORA C. B.; YOKOO, SAMI; GRANATO, DANIELA C.; MENEGUELLO, LETICIA; CARNIELLI, CAROLINA M.; TAVARES, MARIANA R.; DO AMARAL, CAMILA L.; DE FREITAS, LIDIA B.; PAES LEME, ADRIANA F.; LUCHESSI, AUGUSTO D.; et al. Different interactomes for p70-S6K1 and p54-S6K2 revealed by proteomic analysis. PROTEOMICS, v. 16, n. 20, p. 2650-2666, . (14/01386-2, 13/22696-7, 12/13558-7)

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