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Standardization of polar extracts of the aerial parts of Actinocephalus divaricatus (Koern.) Sano (Eriocaulaceae) by HPLC-PDA

Grant number: 14/04593-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2014
Effective date (End): June 26, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Lourdes Campaner dos Santos
Grantee:Ana Caroline Zanatta Silva
Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):15/00809-0 - Metabolite fingerprinting of aerial parts of Actinocephalus divaricatus (Koern.) Sano (Eriocaulaceae) by LC-ESI-MS, BE.EP.MS


The sempre-vivas are increasingly commercially exploited, both nationally and internationally plants. However, most are endemic to Brazil and some species are at serious risk of extinction. The major difficulty in studying chemically extracts of these species is the low mass offered to perform of step phytochemical and to obtain mass quantities necessary to carry out the biological assays and often even to the identification of the molecule by spectroscopic methods. However, studies of the chemical species must be continued since there are hundreds of species without studies. The Coupled to the Diode Array Detector (HPLC -PDA) High Performance Liquid Chromatography has provided a qualitative study of plant extracts and quantitiativo quickly, efficiently and with little use for mass analysis way. Our research group has studied species Eriocaulaceae for over two decades, resulting in the isolation and identification of a hundred molecules, some existing ones in the literature with antioxidant, cytotoxic, anti-ulcer, anti-inflammatory properties, bowel diseases, ulcerative colitis and unpublished Crohn´s Disease. Thus, this plant family has an interesting chemical, comprising biologically active molecules. Therefore, this project aims to study the polar extracts of chapters, scapes and leaves Actinocephalus divaricatus belonging to Eriocaulaceae by coupled HPLC-PDA technique, allowing a quick and effective qualitative and quantitative analysis, allowing the identification of existing metabolites in extracts polar species proposed for study in this research project. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZANATTA, ANA C.; MARI, ANGELA; MASULLO, MILENA; CARLOS, IRACILDA ZEPPONE; VILEGAS, WAGNER; PIACENTE, SONIA; DOS SANTOS, LOURDES CAMPANER. Chemical metabolome assay by high-resolution Orbitrap mass spectrometry and assessment of associated antitumoral activity of Actinocephalus divaricatus. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 32, n. 3, p. 241-250, . (15/00809-0, 15/04899-3, 14/04593-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Ana Caroline Zanatta. Standardization of polar extracts of the aerial parts of Actinocephalus divaricatus (Körn.) Sano (Eriocaulaceae). 2016. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Química. Araraquara Araraquara.

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