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Chitosan-based tissue engineered vascular grafts

Grant number: 13/26534-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2014
Effective date (End): September 30, 2018
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal Investigator:Angela Maria Moraes
Grantee:Fernanda Carla Bombaldi de Souza
Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):17/01858-0 - Chitosan-based scaffolds for vascular tissue engineering: mechanical characterization and cell culture on tubular matrices, BE.EP.DR


Cardiovascular diseases such as atherosclerosis, coronary artery and peripheral vascular diseases are the leading causes of death worldwide and often require surgical intervention to replace damaged blood vessels, restore blood flow and preserve functions of lesioned tissues. The materials currently available for this therapy are efficient only when used to replace blood vessels with diameter greater than six millimeters due to complications related to the immune response observed in smaller diameter devices. Tissue engineering is an alternative technique used to overcome the problems that give rise to these complications, comprising of the seeding of mesenchymal stem cells on biodegradable scaffolds for the development of vascular grafts. Natural polymers such as chitosan are widely used as scaffolds as they provide matrices which are able to facilitate cell growth. Various compounds, namely the polysaccharides alginate and pectin, as well as the silicone based polymers such as Silpuran®, are capable of forming complexes or blends with chitosan, and these combinations can contribute to the improvement of the biomaterials properties. In this context , the use of chitosan in combination or not with other compounds for obtaining dense or porous biocompatible matrices used for cell growth and applied as vascular grafts are the focus of this proposal. The vascular grafts produced will be evaluated according to their physicochemical, mechanical and biological properties and the performance of the seeded mesenchymal stem cells will be evaluated. In addition, the devices will be compared to each other to determine which formulation has the most appropriate characteristics to the desired application.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOMBALDI DE SOUZA, FERNANDA CARLA; BOMBALDI DE SOUZA, RENATA FRANCIELLE; DROUIN, BERNARD; MANTOVANI, DIEGO; MORAES, ANGELA MARIA. Comparative study on complexes formed by chitosan and different polyanions: Potential of chitosan-pectin biomaterials as scaffolds in tissue engineering. International Journal of Biological Macromolecules, v. 132, p. 178-189, . (17/01858-0, 13/26534-1)
BOMBALDI DE SOUZA, FERNANDA CARLA; BOMBALDI DE SOUZA, RENATA FRANCIELLE; DROUIN, BERNARD; POPAT, KETUL C.; MANTOVANI, DIEGO; MORAES, ANGELA MARIA. Polysaccharide-based tissue-engineered vascular patches. Materials Science & Engineering C-Materials for Biological Applications, v. 104, . (13/26534-1, 17/01858-0)
BOMBALDI DE SOUZA, FERNANDA CARLA; CANNASAO, DIMITRIA BONIZOL; BOMBALDI DE SOUZA, RENATA FRANCIELLE; DROUIN, BERNARD; MANTOVANI, DIEGO; MORAES, ANGELA MARIA. A simple and effective approach to produce tubular polysaccharide-based hydrogel scaffolds. Journal of Applied Polymer Science, v. 137, n. 13, . (17/01858-0, 13/26534-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Fernanda Carla Bombaldi de. Three-dimensional structures obtained by complexation of chitosan with other polysaccharides for application in vascular tissue engineering. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Química Campinas, SP.

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